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- W262433991 endingPage "2091" @default.
- W262433991 startingPage "2088" @default.
- W262433991 abstract "Abstract Neutrophil specific granule deficiency (SGD) is a rare congenital disorder of unknown cause associated with an impaired inflammatory response and an absence of neutrophil secondary granules. Reduced levels of several neutrophil proteins have led to the suggestion that the defect may lie at the level of transcription, a hypothesis that is supported by abnormally low levels of lactoferrin message in the bone marrow of two SGD patients. We have examined the level of seven granule protein RNAs in one SGD patient and have compared them with reported protein levels. We have found the RNA levels for all of these genes to be reduced in proportion to the decreased levels of their respective proteins. These data further support the hypothesis that the reduced protein levels reflect a defect in transcriptional control." @default.
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- W262433991 date "1992-10-15" @default.
- W262433991 modified "2023-09-30" @default.
- W262433991 title "Correlation of messenger RNA levels with protein defects in specific granule deficiency" @default.
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- W262433991 doi "https://doi.org/10.1182/blood.v80.8.2088.2088" @default.
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