Matches in SemOpenAlex for { <https://semopenalex.org/work/W2624370818> ?p ?o ?g. }
- W2624370818 endingPage "1000" @default.
- W2624370818 startingPage "996" @default.
- W2624370818 abstract "Background: Liver injury caused by traditional Chinese medicines (TCMs) is reported from many countries around the world. TCM hepatotoxicity has attracted worldwide concerns.Objective: This study aims to develop a more applicable and optimal tool to evaluate TCM hepatotoxicity.Methods: A quantitative structure-activity relationship (QSAR) analysis was performed based on published data and U.S. Food and Drug Administration’s Liver Toxicity Knowledge Base (LTKB).Results: Eleven herbal ingredients with proven liver toxicity in the literature were added into the dataset besides chemicals from LTKB. The finally generated QSAR model yielded a sensitivity of 83.8%, a specificity of 70.1%, and an accuracy of 80.2%. Among the externally tested 20 ingredients from TCMs, 14 hepatotoxic ingredients were all accurately identified by the QSAR model derived from the dataset containing natural hepatotoxins.Conclusions: Adding natural hepatotoxins into the dataset makes the QSAR model more applicable for TCM hepatotoxicity assessment, which provides a right direction in the methodology study for TCM safety evaluation. The generated QSAR model has the practical value to prioritize the hepatotoxicity risk of TCM compounds. Furthermore, an open-access international specialized database on TCM hepatotoxicity should be quickly established." @default.
- W2624370818 created "2017-06-15" @default.
- W2624370818 creator A5047327817 @default.
- W2624370818 creator A5048826252 @default.
- W2624370818 creator A5049705188 @default.
- W2624370818 creator A5083445014 @default.
- W2624370818 date "2017-06-08" @default.
- W2624370818 modified "2023-10-16" @default.
- W2624370818 title "Hepatotoxicity evaluation of traditional Chinese medicines using a computational molecular model" @default.
- W2624370818 cites W1490747191 @default.
- W2624370818 cites W1552719054 @default.
- W2624370818 cites W1578468824 @default.
- W2624370818 cites W1763632026 @default.
- W2624370818 cites W1917479864 @default.
- W2624370818 cites W1963568502 @default.
- W2624370818 cites W1966052797 @default.
- W2624370818 cites W1967213489 @default.
- W2624370818 cites W1968066048 @default.
- W2624370818 cites W1976148540 @default.
- W2624370818 cites W1978931025 @default.
- W2624370818 cites W2010524461 @default.
- W2624370818 cites W2014141124 @default.
- W2624370818 cites W2028900142 @default.
- W2624370818 cites W2029497311 @default.
- W2624370818 cites W2029548715 @default.
- W2624370818 cites W2032891608 @default.
- W2624370818 cites W2034611805 @default.
- W2624370818 cites W2040872040 @default.
- W2624370818 cites W2049947626 @default.
- W2624370818 cites W2053623949 @default.
- W2624370818 cites W2059745228 @default.
- W2624370818 cites W2063234159 @default.
- W2624370818 cites W2073314310 @default.
- W2624370818 cites W2075352120 @default.
- W2624370818 cites W2080505481 @default.
- W2624370818 cites W2081732967 @default.
- W2624370818 cites W2086486239 @default.
- W2624370818 cites W2087561463 @default.
- W2624370818 cites W2091173889 @default.
- W2624370818 cites W2109879824 @default.
- W2624370818 cites W2114130861 @default.
- W2624370818 cites W2119798433 @default.
- W2624370818 cites W2123676318 @default.
- W2624370818 cites W2134188261 @default.
- W2624370818 cites W2139307881 @default.
- W2624370818 cites W2144101181 @default.
- W2624370818 cites W2149306036 @default.
- W2624370818 cites W2192028118 @default.
- W2624370818 cites W2243263471 @default.
- W2624370818 cites W2315235891 @default.
- W2624370818 cites W2317818937 @default.
- W2624370818 cites W2336726309 @default.
- W2624370818 cites W2461691410 @default.
- W2624370818 cites W3022283892 @default.
- W2624370818 cites W841521549 @default.
- W2624370818 doi "https://doi.org/10.1080/15563650.2017.1333123" @default.
- W2624370818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28594241" @default.
- W2624370818 hasPublicationYear "2017" @default.
- W2624370818 type Work @default.
- W2624370818 sameAs 2624370818 @default.
- W2624370818 citedByCount "16" @default.
- W2624370818 countsByYear W26243708182018 @default.
- W2624370818 countsByYear W26243708182019 @default.
- W2624370818 countsByYear W26243708182020 @default.
- W2624370818 countsByYear W26243708182021 @default.
- W2624370818 countsByYear W26243708182023 @default.
- W2624370818 crossrefType "journal-article" @default.
- W2624370818 hasAuthorship W2624370818A5047327817 @default.
- W2624370818 hasAuthorship W2624370818A5048826252 @default.
- W2624370818 hasAuthorship W2624370818A5049705188 @default.
- W2624370818 hasAuthorship W2624370818A5083445014 @default.
- W2624370818 hasConcept C116263406 @default.
- W2624370818 hasConcept C119857082 @default.
- W2624370818 hasConcept C126322002 @default.
- W2624370818 hasConcept C142724271 @default.
- W2624370818 hasConcept C149971331 @default.
- W2624370818 hasConcept C164126121 @default.
- W2624370818 hasConcept C188947578 @default.
- W2624370818 hasConcept C204787440 @default.
- W2624370818 hasConcept C2780035454 @default.
- W2624370818 hasConcept C29730261 @default.
- W2624370818 hasConcept C2993709057 @default.
- W2624370818 hasConcept C41008148 @default.
- W2624370818 hasConcept C556039675 @default.
- W2624370818 hasConcept C71924100 @default.
- W2624370818 hasConcept C98274493 @default.
- W2624370818 hasConceptScore W2624370818C116263406 @default.
- W2624370818 hasConceptScore W2624370818C119857082 @default.
- W2624370818 hasConceptScore W2624370818C126322002 @default.
- W2624370818 hasConceptScore W2624370818C142724271 @default.
- W2624370818 hasConceptScore W2624370818C149971331 @default.
- W2624370818 hasConceptScore W2624370818C164126121 @default.
- W2624370818 hasConceptScore W2624370818C188947578 @default.
- W2624370818 hasConceptScore W2624370818C204787440 @default.
- W2624370818 hasConceptScore W2624370818C2780035454 @default.
- W2624370818 hasConceptScore W2624370818C29730261 @default.
- W2624370818 hasConceptScore W2624370818C2993709057 @default.
- W2624370818 hasConceptScore W2624370818C41008148 @default.