Matches in SemOpenAlex for { <https://semopenalex.org/work/W2624399612> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2624399612 endingPage "S19" @default.
- W2624399612 startingPage "S19" @default.
- W2624399612 abstract "Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-related death all over the world. This disease is difficult to treat and patients have an overall 5-year survival rate of less than 5%. Although two drugs, gemcitabine (GEM) and 5-fluorouracil (5-FU) have been shown to improve the survival rate of patients systematically, they do not increase general survival to a clinically acceptable degree. Lack of ideal clinical response of pancreatic cancer patients to chemotherapy is likely to be due to intrinsic and acquired chemoresistance of tumor cells. Various mechanisms of drug resistance have been investigated in pancreatic cancer, including genetic and epigenetic changes in particular genes or signaling pathways. In addition, evidence suggests that microRNAs (miRNAs) play significant roles as key regulators of gene expression in many cellular processes, including drug resistance. Understanding underlying genes and mechanisms of drug resistance in pancreatic cancer is critical to develop new effective treatments for this deadly disease. This review illustrates the genes and miRNAs involved in resistance to gemcitabine in pancreatic cancer." @default.
- W2624399612 created "2017-06-15" @default.
- W2624399612 creator A5002724974 @default.
- W2624399612 creator A5049731648 @default.
- W2624399612 creator A5057254837 @default.
- W2624399612 creator A5058448191 @default.
- W2624399612 creator A5061218399 @default.
- W2624399612 creator A5068092442 @default.
- W2624399612 creator A5078518284 @default.
- W2624399612 creator A5085409864 @default.
- W2624399612 creator A5090973852 @default.
- W2624399612 creator A5088965175 @default.
- W2624399612 date "2017-07-01" @default.
- W2624399612 modified "2023-10-18" @default.
- W2624399612 title "Fibroblastic FAK controls pancreatic cancer metastasis by enhancing extracellular matrix remodeling" @default.
- W2624399612 doi "https://doi.org/10.1016/j.pan.2017.05.061" @default.
- W2624399612 hasPublicationYear "2017" @default.
- W2624399612 type Work @default.
- W2624399612 sameAs 2624399612 @default.
- W2624399612 citedByCount "0" @default.
- W2624399612 crossrefType "journal-article" @default.
- W2624399612 hasAuthorship W2624399612A5002724974 @default.
- W2624399612 hasAuthorship W2624399612A5049731648 @default.
- W2624399612 hasAuthorship W2624399612A5057254837 @default.
- W2624399612 hasAuthorship W2624399612A5058448191 @default.
- W2624399612 hasAuthorship W2624399612A5061218399 @default.
- W2624399612 hasAuthorship W2624399612A5068092442 @default.
- W2624399612 hasAuthorship W2624399612A5078518284 @default.
- W2624399612 hasAuthorship W2624399612A5085409864 @default.
- W2624399612 hasAuthorship W2624399612A5088965175 @default.
- W2624399612 hasAuthorship W2624399612A5090973852 @default.
- W2624399612 hasConcept C104317684 @default.
- W2624399612 hasConcept C114851261 @default.
- W2624399612 hasConcept C121608353 @default.
- W2624399612 hasConcept C126322002 @default.
- W2624399612 hasConcept C143998085 @default.
- W2624399612 hasConcept C145059251 @default.
- W2624399612 hasConcept C2776694085 @default.
- W2624399612 hasConcept C2779013556 @default.
- W2624399612 hasConcept C2779134260 @default.
- W2624399612 hasConcept C2780210213 @default.
- W2624399612 hasConcept C2780258809 @default.
- W2624399612 hasConcept C41091548 @default.
- W2624399612 hasConcept C502942594 @default.
- W2624399612 hasConcept C55493867 @default.
- W2624399612 hasConcept C60644358 @default.
- W2624399612 hasConcept C71924100 @default.
- W2624399612 hasConcept C86803240 @default.
- W2624399612 hasConcept C89423630 @default.
- W2624399612 hasConceptScore W2624399612C104317684 @default.
- W2624399612 hasConceptScore W2624399612C114851261 @default.
- W2624399612 hasConceptScore W2624399612C121608353 @default.
- W2624399612 hasConceptScore W2624399612C126322002 @default.
- W2624399612 hasConceptScore W2624399612C143998085 @default.
- W2624399612 hasConceptScore W2624399612C145059251 @default.
- W2624399612 hasConceptScore W2624399612C2776694085 @default.
- W2624399612 hasConceptScore W2624399612C2779013556 @default.
- W2624399612 hasConceptScore W2624399612C2779134260 @default.
- W2624399612 hasConceptScore W2624399612C2780210213 @default.
- W2624399612 hasConceptScore W2624399612C2780258809 @default.
- W2624399612 hasConceptScore W2624399612C41091548 @default.
- W2624399612 hasConceptScore W2624399612C502942594 @default.
- W2624399612 hasConceptScore W2624399612C55493867 @default.
- W2624399612 hasConceptScore W2624399612C60644358 @default.
- W2624399612 hasConceptScore W2624399612C71924100 @default.
- W2624399612 hasConceptScore W2624399612C86803240 @default.
- W2624399612 hasConceptScore W2624399612C89423630 @default.
- W2624399612 hasIssue "3" @default.
- W2624399612 hasLocation W26243996121 @default.
- W2624399612 hasOpenAccess W2624399612 @default.
- W2624399612 hasPrimaryLocation W26243996121 @default.
- W2624399612 hasRelatedWork W114644245 @default.
- W2624399612 hasRelatedWork W1975859778 @default.
- W2624399612 hasRelatedWork W2091301590 @default.
- W2624399612 hasRelatedWork W2252870908 @default.
- W2624399612 hasRelatedWork W2376347278 @default.
- W2624399612 hasRelatedWork W2626414898 @default.
- W2624399612 hasRelatedWork W3029364823 @default.
- W2624399612 hasRelatedWork W3031009328 @default.
- W2624399612 hasRelatedWork W3031675857 @default.
- W2624399612 hasRelatedWork W4254486378 @default.
- W2624399612 hasVolume "17" @default.
- W2624399612 isParatext "false" @default.
- W2624399612 isRetracted "false" @default.
- W2624399612 magId "2624399612" @default.
- W2624399612 workType "article" @default.