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• W2624489531 abstract "Abstract Retinitis pigmentosa ( RP ) comprises a group of incurable inherited retinal degenerations. Targeting common processes, instead of mutation‐specific treatment, has proven to be an innovative strategy to combat debilitating retinal degeneration. Growing evidence indicates that melatonin possesses a potent activity against neurodegenerative disorders by mitigating cell damage associated with apoptosis and inflammation. Given the pleiotropic role of melatonin in central nervous system, the aim of the present study was to investigate whether melatonin would afford protection against retinal degeneration in autosomal recessive RP (ar RP ). Rd10 , a well‐characterized murine model of human ar RP , received daily intraperitoneal injection of melatonin (15 mg/kg) between postnatal day (P) 13 and P30. Retinas treated with melatonin or vehicle were harvested for analysis at P30 and P45, respectively. The findings showed that melatonin could dampen the photoreceptors death and delay consequent retinal degeneration. We also observed that melatonin weakened the expression of glial fibrillary acidic protein ( GFAP ) in Müller cells. Additionally, melatonin could alleviate retinal inflammatory response visualized by IBA 1 staining, which was further corroborated by downregulation of inflammation‐related genes, such as tumor necrosis factor alpha ( Tnf‐ α) , chemokine (C‐C motif) ligand 2 ( Ccl2 ), and chemokine (C‐X‐C motif) ligand 10 ( Cxcl10 ). These data revealed that melatonin could ameliorate retinal degeneration through potentially attenuating apoptosis, reactive gliosis, and microglial activation in rd10 mice. Moreover, these results suggest melatonin as a promising agent improving photoreceptors survival in human RP ." @default.
• W2624489531 created "2017-06-15" @default.
• W2624489531 creator A5004220950 @default.
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• W2624489531 date "2017-06-20" @default.
• W2624489531 modified "2023-10-04" @default.
• W2624489531 title "Melatonin delays photoreceptor degeneration in a mouse model of autosomal recessive retinitis pigmentosa" @default.
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• W2624489531 doi "https://doi.org/10.1111/jpi.12428" @default.
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• W2624489531 hasPublicationYear "2017" @default.
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