Matches in SemOpenAlex for { <https://semopenalex.org/work/W2624489940> ?p ?o ?g. }
- W2624489940 abstract "Caveolin-1 (CAV1), the major constituent of caveolae, plays a pivotal role in various cellular biological functions, including cancer and inflammation. The ubiquitin/proteasomal pathway is known to contribute to the regulation of CAV1 expression, but the ubiquitin ligase responsible for CAV1 protein stability remains unidentified. Here we reveal that E3 ubiquitin ligase ZNRF1 modulates CAV1 protein stability to regulate Toll-like receptor (TLR) 4-triggered immune responses. We demonstrate that ZNRF1 physically interacts with CAV1 in response to lipopolysaccharide and mediates ubiquitination and degradation of CAV1. The ZNRF1-CAV1 axis regulates Akt-GSK3β activity upon TLR4 activation, resulting in enhanced production of pro-inflammatory cytokines and inhibition of anti-inflammatory cytokine IL-10. Mice with deletion of ZNRF1 in their hematopoietic cells display increased resistance to endotoxic and polymicrobial septic shock due to attenuated inflammation. Our study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1." @default.
- W2624489940 created "2017-06-15" @default.
- W2624489940 creator A5002244676 @default.
- W2624489940 creator A5010256009 @default.
- W2624489940 creator A5052912780 @default.
- W2624489940 creator A5060869513 @default.
- W2624489940 creator A5073722954 @default.
- W2624489940 creator A5080081145 @default.
- W2624489940 creator A5081451789 @default.
- W2624489940 creator A5084071892 @default.
- W2624489940 creator A5085426512 @default.
- W2624489940 creator A5087997465 @default.
- W2624489940 creator A5088655396 @default.
- W2624489940 date "2017-06-08" @default.
- W2624489940 modified "2023-10-06" @default.
- W2624489940 title "The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation" @default.
- W2624489940 cites W1581618913 @default.
- W2624489940 cites W1927872630 @default.
- W2624489940 cites W1968267890 @default.
- W2624489940 cites W1969175670 @default.
- W2624489940 cites W1974993490 @default.
- W2624489940 cites W1975718576 @default.
- W2624489940 cites W1994176403 @default.
- W2624489940 cites W1994942139 @default.
- W2624489940 cites W1997181834 @default.
- W2624489940 cites W1997640131 @default.
- W2624489940 cites W1999604675 @default.
- W2624489940 cites W2002594335 @default.
- W2624489940 cites W2007547890 @default.
- W2624489940 cites W2014903703 @default.
- W2624489940 cites W2015472023 @default.
- W2624489940 cites W2015665561 @default.
- W2624489940 cites W2017118245 @default.
- W2624489940 cites W2023179617 @default.
- W2624489940 cites W2023945291 @default.
- W2624489940 cites W2027433961 @default.
- W2624489940 cites W2028790868 @default.
- W2624489940 cites W2033023829 @default.
- W2624489940 cites W2038970416 @default.
- W2624489940 cites W2042295490 @default.
- W2624489940 cites W2043823247 @default.
- W2624489940 cites W2044736496 @default.
- W2624489940 cites W2046804517 @default.
- W2624489940 cites W2048926039 @default.
- W2624489940 cites W2053731989 @default.
- W2624489940 cites W2058138221 @default.
- W2624489940 cites W2062934426 @default.
- W2624489940 cites W2073168231 @default.
- W2624489940 cites W2084740946 @default.
- W2624489940 cites W2102911609 @default.
- W2624489940 cites W2104500013 @default.
- W2624489940 cites W2106684817 @default.
- W2624489940 cites W2108830583 @default.
- W2624489940 cites W2110201472 @default.
- W2624489940 cites W2114733747 @default.
- W2624489940 cites W2115617484 @default.
- W2624489940 cites W2118390380 @default.
- W2624489940 cites W2119377963 @default.
- W2624489940 cites W2125867335 @default.
- W2624489940 cites W2126099199 @default.
- W2624489940 cites W2128963767 @default.
- W2624489940 cites W2132675832 @default.
- W2624489940 cites W2133439754 @default.
- W2624489940 cites W2139864039 @default.
- W2624489940 cites W2140456056 @default.
- W2624489940 cites W2151527536 @default.
- W2624489940 cites W2160269020 @default.
- W2624489940 cites W2163278196 @default.
- W2624489940 cites W2166373023 @default.
- W2624489940 cites W2187911644 @default.
- W2624489940 cites W2262573558 @default.
- W2624489940 cites W2280404143 @default.
- W2624489940 cites W2620241325 @default.
- W2624489940 cites W3214706838 @default.
- W2624489940 doi "https://doi.org/10.1038/ncomms15502" @default.
- W2624489940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5472178" @default.
- W2624489940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28593998" @default.
- W2624489940 hasPublicationYear "2017" @default.
- W2624489940 type Work @default.
- W2624489940 sameAs 2624489940 @default.
- W2624489940 citedByCount "36" @default.
- W2624489940 countsByYear W26244899402017 @default.
- W2624489940 countsByYear W26244899402018 @default.
- W2624489940 countsByYear W26244899402019 @default.
- W2624489940 countsByYear W26244899402020 @default.
- W2624489940 countsByYear W26244899402021 @default.
- W2624489940 countsByYear W26244899402022 @default.
- W2624489940 countsByYear W26244899402023 @default.
- W2624489940 crossrefType "journal-article" @default.
- W2624489940 hasAuthorship W2624489940A5002244676 @default.
- W2624489940 hasAuthorship W2624489940A5010256009 @default.
- W2624489940 hasAuthorship W2624489940A5052912780 @default.
- W2624489940 hasAuthorship W2624489940A5060869513 @default.
- W2624489940 hasAuthorship W2624489940A5073722954 @default.
- W2624489940 hasAuthorship W2624489940A5080081145 @default.
- W2624489940 hasAuthorship W2624489940A5081451789 @default.
- W2624489940 hasAuthorship W2624489940A5084071892 @default.
- W2624489940 hasAuthorship W2624489940A5085426512 @default.
- W2624489940 hasAuthorship W2624489940A5087997465 @default.
- W2624489940 hasAuthorship W2624489940A5088655396 @default.