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- W2624534319 abstract "Exercise-induced leukocytosis is a striking and consistent observation. We hypothesized that pre-exercise (PreE) leukocyte levels could explain much of the variation in exercise neutrophilia. The contribution of asthma, fitness, exercise duration and PreE leukocyte levels to exercise-induced neutrophilia was analyzed using regression. Healthy (n=80) and asthmatic (n=26) children completed either 8 or 30-min of exercise at 85% of max capacity. Fitness measures included VO2max and %BF by DEXA. Blood was collected 30-min after IV placement (PreE) and immediately after exercise (PostE). Total leukocyte increased 51%, monocytes 93%, lymphs 64%, and eosinophils and basophils 30% and 18% respectively. Neutrophils increased 46% with exercise, (PreE 2878.5 + 1220.3, PostE 4058.7 + 1535.2). Higher PostE neutrophilia was associated with lower PreE neutrophils β= −0.41, higher PreE monocytes β=0.38, and greater body weight β=0.25 and duration of exercise β=0.19 (F=11.5, (4,95), p<.001). Gender, asthma, and fitness did not influence neutrophilia. Higher PreE neutrophils were associated with higher PreE leukocyte count (β=.903) increased age (β=.25), and less body wt (β=−.20, F=146.3, (3,99), p<.001). In conclusion, for both asthmatic and healthy children, pre-exercise leukocyte levels influence the acute immune response to short bouts of exercise. This research is supported by R01 HL80947, PO1HD048721." @default.
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- W2624534319 date "2007-01-01" @default.
- W2624534319 modified "2023-09-26" @default.
- W2624534319 title "Factors influencing exercise‐induced neutrophilia in children" @default.
- W2624534319 doi "https://doi.org/10.1096/fasebj.21.6.a933-c" @default.
- W2624534319 hasPublicationYear "2007" @default.
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