FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2624572223> ?p ?o ?g. }

• W2624572223 endingPage "1220" @default.
• W2624572223 startingPage "1206" @default.
• W2624572223 abstract "Abstract Alternative usage of transcript isoforms from the same gene has been hypothesized as an important feature in cancers. However, differential usage of gene transcripts between conditions (isoform switching) has not been comprehensively characterized in and across cancer types. To this end, we developed methods for identification and visualization of isoform switches with predicted functional consequences. Using these methods, we characterized isoform switching in RNA-seq data from &gt;5,500 cancer patients covering 12 solid cancer types. Isoform switches with potential functional consequences were common, affecting approximately 19% of multiple transcript genes. Among these, isoform switches leading to loss of DNA sequence encoding protein domains were more frequent than expected, particularly in pancancer switches. We identified several isoform switches as powerful biomarkers: 31 switches were highly predictive of patient survival independent of cancer types. Our data constitute an important resource for cancer researchers, available through interactive web tools. Moreover, our methods, available as an R package, enable systematic analysis of isoform switches from other RNA-seq datasets. Implications: This study indicates that isoform switches with predicted functional consequences are common and important in dysfunctional cells, which in turn means that gene expression should be analyzed at the isoform level. Visual Overview: http://mcr.aacrjournals.org/content/molcanres/15/9/1206/F1.large.jpg. Mol Cancer Res; 15(9); 1206–20. ©2017 AACR." @default.
• W2624572223 created "2017-06-15" @default.
• W2624572223 creator A5026910430 @default.
• W2624572223 creator A5037239114 @default.
• W2624572223 date "2017-08-31" @default.
• W2624572223 modified "2023-10-17" @default.
• W2624572223 title "The Landscape of Isoform Switches in Human Cancers" @default.
• W2624572223 cites W1526938021 @default.
• W2624572223 cites W1570622790 @default.
• W2624572223 cites W1816176398 @default.
• W2624572223 cites W1871669466 @default.
• W2624572223 cites W1914507546 @default.
• W2624572223 cites W1968239355 @default.
• W2624572223 cites W1968291759 @default.
• W2624572223 cites W1986223165 @default.
• W2624572223 cites W1999574084 @default.
• W2624572223 cites W2010457001 @default.
• W2624572223 cites W2011920499 @default.
• W2624572223 cites W2024036230 @default.
• W2624572223 cites W2030637794 @default.
• W2624572223 cites W2048194168 @default.
• W2624572223 cites W2050258759 @default.
• W2624572223 cites W2050625792 @default.
• W2624572223 cites W2057692691 @default.
• W2624572223 cites W2060383308 @default.
• W2624572223 cites W2068274700 @default.
• W2624572223 cites W2075318911 @default.
• W2624572223 cites W2089047063 @default.
• W2624572223 cites W2093131463 @default.
• W2624572223 cites W2094074349 @default.
• W2624572223 cites W2094201044 @default.
• W2624572223 cites W2096173332 @default.
• W2624572223 cites W2105749202 @default.
• W2624572223 cites W2112954412 @default.
• W2624572223 cites W2124501579 @default.
• W2624572223 cites W2126669467 @default.
• W2624572223 cites W2128012941 @default.
• W2624572223 cites W2141458291 @default.
• W2624572223 cites W2150877305 @default.
• W2624572223 cites W2151462466 @default.
• W2624572223 cites W2151873427 @default.
• W2624572223 cites W2155804510 @default.
• W2624572223 cites W2158485828 @default.
• W2624572223 cites W2166820820 @default.
• W2624572223 cites W2197124664 @default.
• W2624572223 cites W2259938310 @default.
• W2624572223 cites W2291502897 @default.
• W2624572223 cites W2323326409 @default.
• W2624572223 cites W2345688099 @default.
• W2624572223 cites W2413782718 @default.
• W2624572223 cites W2419587273 @default.
• W2624572223 cites W2513371636 @default.
• W2624572223 cites W2558715006 @default.
• W2624572223 cites W4320301318 @default.
• W2624572223 doi "https://doi.org/10.1158/1541-7786.mcr-16-0459" @default.
• W2624572223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28584021" @default.
• W2624572223 hasPublicationYear "2017" @default.
• W2624572223 type Work @default.
• W2624572223 sameAs 2624572223 @default.
• W2624572223 citedByCount "163" @default.
• W2624572223 countsByYear W26245722232017 @default.
• W2624572223 countsByYear W26245722232018 @default.
• W2624572223 countsByYear W26245722232019 @default.
• W2624572223 countsByYear W26245722232020 @default.
• W2624572223 countsByYear W26245722232021 @default.
• W2624572223 countsByYear W26245722232022 @default.
• W2624572223 countsByYear W26245722232023 @default.
• W2624572223 crossrefType "journal-article" @default.
• W2624572223 hasAuthorship W2624572223A5026910430 @default.
• W2624572223 hasAuthorship W2624572223A5037239114 @default.
• W2624572223 hasConcept C104317684 @default.
• W2624572223 hasConcept C121608353 @default.
• W2624572223 hasConcept C502942594 @default.
• W2624572223 hasConcept C53345823 @default.
• W2624572223 hasConcept C54355233 @default.
• W2624572223 hasConcept C60644358 @default.
• W2624572223 hasConcept C70721500 @default.
• W2624572223 hasConcept C86803240 @default.
• W2624572223 hasConceptScore W2624572223C104317684 @default.
• W2624572223 hasConceptScore W2624572223C121608353 @default.
• W2624572223 hasConceptScore W2624572223C502942594 @default.
• W2624572223 hasConceptScore W2624572223C53345823 @default.
• W2624572223 hasConceptScore W2624572223C54355233 @default.
• W2624572223 hasConceptScore W2624572223C60644358 @default.
• W2624572223 hasConceptScore W2624572223C70721500 @default.
• W2624572223 hasConceptScore W2624572223C86803240 @default.
• W2624572223 hasIssue "9" @default.
• W2624572223 hasLocation W26245722231 @default.
• W2624572223 hasLocation W26245722232 @default.
• W2624572223 hasOpenAccess W2624572223 @default.
• W2624572223 hasPrimaryLocation W26245722231 @default.
• W2624572223 hasRelatedWork W1991523530 @default.
• W2624572223 hasRelatedWork W2002128513 @default.
• W2624572223 hasRelatedWork W2020824267 @default.
• W2624572223 hasRelatedWork W2020838698 @default.
• W2624572223 hasRelatedWork W2031436818 @default.
• W2624572223 hasRelatedWork W2057739827 @default.
• W2624572223 hasRelatedWork W2075354549 @default.

• next