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• W2624588518 abstract "Previous in vivo and in vitro studies have linked perfluorinated compound (PFC) exposure with metabolic interruption, but the inter-species difference and high treatment doses usually make the results difficult to be extrapolated to humans directly. The best strategy for identifying the metabolic interruption may be to establish the direct correlations between monitored PFCs data and metabolic data on human samples. In this study, serum metabolome data and PFC concentrations were acquired for a Chinese adult male cohort. The most abundant PFCs are PFOA and PFOS with concentration medians 7.56 and 12.78 nM, respectively; in together they count around 81.6% of the total PFCs. PFC concentration-related serum metabolic profile changes and the related metabolic biomarkers were explored by using partial least squares-discriminant analysis (PLS-DA). Respectively taking PFOS, PFOA and total PFC as the classifiers, serum metabolome can be differentiated between the lowest dose group (1st quartile PFCs) and the highest PFC dose group (4th quartile PFCs). Ten potential PFC biomarkers were identified, mainly involving in pollutant detoxification, antioxidation and nitric oxide (NO) signal pathways. These suggested that low-level environmental PFC exposure has significantly adverse impacts on glutathione (GSH) cycle, Krebs cycle, nitric oxide (NO) generation and purine oxidation in humans. To the best of our knowledge, this is the first report investigating the association of environmental PFC exposure with human serum metabolome alteration. Given the important biological functions of the identified biomarkers, we suggest that PFC could increase the metabolism syndromes risk including diabetes and cardiovascular diseases." @default.
• W2624588518 created "2017-06-15" @default.
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• W2624588518 date "2017-10-01" @default.
• W2624588518 modified "2023-10-16" @default.
• W2624588518 title "Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative /nitrosative stress in humans" @default.
• W2624588518 cites W1968813633 @default.
• W2624588518 cites W1973654733 @default.
• W2624588518 cites W1975189578 @default.
• W2624588518 cites W1976770880 @default.
• W2624588518 cites W1976878552 @default.
• W2624588518 cites W1978522426 @default.
• W2624588518 cites W1984648008 @default.
• W2624588518 cites W1985092629 @default.
• W2624588518 cites W1986194759 @default.
• W2624588518 cites W1986258895 @default.
• W2624588518 cites W1988292100 @default.
• W2624588518 cites W1988860623 @default.
• W2624588518 cites W1990993613 @default.
• W2624588518 cites W1994346346 @default.
• W2624588518 cites W1997495771 @default.
• W2624588518 cites W1997592674 @default.
• W2624588518 cites W2000375533 @default.
• W2624588518 cites W2004138108 @default.
• W2624588518 cites W2005527892 @default.
• W2624588518 cites W2008547378 @default.
• W2624588518 cites W2008650677 @default.
• W2624588518 cites W2014235257 @default.
• W2624588518 cites W2019637442 @default.
• W2624588518 cites W2024343903 @default.
• W2624588518 cites W2025315910 @default.
• W2624588518 cites W2030183425 @default.
• W2624588518 cites W2032984035 @default.
• W2624588518 cites W2035966708 @default.
• W2624588518 cites W2036747339 @default.
• W2624588518 cites W2039774973 @default.
• W2624588518 cites W2046262374 @default.
• W2624588518 cites W2052360197 @default.
• W2624588518 cites W2053588008 @default.
• W2624588518 cites W2056228772 @default.
• W2624588518 cites W2056601946 @default.
• W2624588518 cites W2059898775 @default.
• W2624588518 cites W2064535527 @default.
• W2624588518 cites W2064790749 @default.
• W2624588518 cites W2068052728 @default.
• W2624588518 cites W2068256216 @default.
• W2624588518 cites W2068382383 @default.
• W2624588518 cites W2072284181 @default.
• W2624588518 cites W2077358897 @default.
• W2624588518 cites W2077824574 @default.
• W2624588518 cites W2079207534 @default.
• W2624588518 cites W2082548756 @default.
• W2624588518 cites W2084742637 @default.
• W2624588518 cites W2087292581 @default.
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• W2624588518 doi "https://doi.org/10.1016/j.envpol.2017.04.086" @default.
• W2624588518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28599201" @default.
• W2624588518 hasPublicationYear "2017" @default.
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