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- W2624634638 abstract "Multipotent mesenchymal stromal cells are considered as a perspective tool in cell therapy and regenerative medicine. Unfortunately, autologous cell therapy does not always provide positive outcomes in elder donors, perhaps as a result of the alterations of stem cell compartments. The mechanisms of stem and progenitor cell senescence and the factors engaged are investigated intensively. In present paper, we elucidated the effects of tissue-related O2 on morphology, functions, and transcriptomic profile of adipose tissue-derived stromal cells (ASCs) in replicative senescence in vitro model. Replicatively senescent ASCs at ambient (20%) O2 (12-21 passages) demonstrated an increased average cell size, granularity, reactive oxygen species level, including anion superoxide, lysosomal compartment activity, and IL-6 production. Decreased ASC viability and proliferation, as well as the change of more than 10 senescence-associated gene expression were detected (IGF1, CDKN1C, ID1, CCND1, etc). Long-term ASC expansion at low O2 (5%) revoked in part the replicative senescence-associated alterations." @default.
- W2624634638 created "2017-06-15" @default.
- W2624634638 creator A5006356752 @default.
- W2624634638 creator A5069652202 @default.
- W2624634638 creator A5088727087 @default.
- W2624634638 date "2017-06-01" @default.
- W2624634638 modified "2023-10-18" @default.
- W2624634638 title "Expansion of adipose tissue-derived stromal cells at “physiologic” hypoxia attenuates replicative senescence" @default.
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- W2624634638 doi "https://doi.org/10.1002/cbf.3267" @default.
- W2624634638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28589682" @default.
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