FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2624659504> ?p ?o ?g. }

• W2624659504 endingPage "26" @default.
• W2624659504 startingPage "17" @default.
• W2624659504 abstract "Jaburetox is a recombinant peptide derived from a Canavalia ensiformis urease that presents toxic effects upon several species of insects, phytopathogenic fungi and yeasts of medical importance. So far, no toxicity of Jaburetox to mammals has been shown. Previous reports have identified biochemical targets of this toxic peptide in insect models, although its mechanism of action is not completely understood. In this work, we aimed to characterize the effects of Jaburetox in hemolymphatic insect cells. For this purpose, the model insect and Chagas' disease vector Rhodnius prolixus was used. In vivo and in vitro experiments indicated that Jaburetox interacts with a subset of hemocytes and it can be found in various subcellular compartments. In insects injected with Jaburetox there was an increase in the gene expression of the enzymes UDP-N-acetylglucosamine pyrophosphorylase (UAP), chitin synthase and nitric oxide synthase (NOS). Nevertheless, the expression of NOS protein, the enzyme activities of UAP and acid phosphatase (a possible link between UAP and NOS) as well as the phosphorylation state of proteins remained unchanged upon the in vivo Jaburetox treatment. Nitric oxide (NO) imaging using fluorescent probes showed that Jaburetox augmented NO production in the hemocyte aggregates when compared to controls. Even though Jaburetox activated the hemocytes, as demonstrated by wheat germ agglutinin binding assays, the peptide did not lead to an increase of their phagocytic behavior. Taken together, these findings contribute to our understanding of toxic effects of Jaburetox, a peptide with biotechnological applications and a prospective tool for rational insect control." @default.
• W2624659504 created "2017-06-15" @default.
• W2624659504 creator A5007929872 @default.
• W2624659504 creator A5011293370 @default.
• W2624659504 creator A5022145074 @default.
• W2624659504 creator A5054035530 @default.
• W2624659504 creator A5072069366 @default.
• W2624659504 creator A5080713696 @default.
• W2624659504 creator A5081780210 @default.
• W2624659504 creator A5087252178 @default.
• W2624659504 date "2017-10-01" @default.
• W2624659504 modified "2023-10-10" @default.
• W2624659504 title "Jaburetox-induced toxic effects on the hemocytes of Rhodnius prolixus (Hemiptera: Reduviidae)" @default.
• W2624659504 cites W1965666159 @default.
• W2624659504 cites W1965833563 @default.
• W2624659504 cites W1971371165 @default.
• W2624659504 cites W1971388896 @default.
• W2624659504 cites W1981812019 @default.
• W2624659504 cites W1985322500 @default.
• W2624659504 cites W1991024927 @default.
• W2624659504 cites W1993109819 @default.
• W2624659504 cites W1993672894 @default.
• W2624659504 cites W2001345438 @default.
• W2624659504 cites W2003587139 @default.
• W2624659504 cites W2008397828 @default.
• W2624659504 cites W2012667043 @default.
• W2624659504 cites W2014389757 @default.
• W2624659504 cites W2020750760 @default.
• W2624659504 cites W2036336524 @default.
• W2624659504 cites W2036641516 @default.
• W2624659504 cites W2046882552 @default.
• W2624659504 cites W2047488767 @default.
• W2624659504 cites W2054867418 @default.
• W2624659504 cites W2057633711 @default.
• W2624659504 cites W2066340912 @default.
• W2624659504 cites W2072536047 @default.
• W2624659504 cites W2078348980 @default.
• W2624659504 cites W2088890614 @default.
• W2624659504 cites W2093765409 @default.
• W2624659504 cites W2104480040 @default.
• W2624659504 cites W2107277218 @default.
• W2624659504 cites W2128859454 @default.
• W2624659504 cites W2137057142 @default.
• W2624659504 cites W2150916538 @default.
• W2624659504 cites W2164759580 @default.
• W2624659504 cites W2169554406 @default.
• W2624659504 cites W2180585235 @default.
• W2624659504 cites W2213316138 @default.
• W2624659504 cites W2220916356 @default.
• W2624659504 cites W2320919827 @default.
• W2624659504 cites W2408219538 @default.
• W2624659504 cites W2486701260 @default.
• W2624659504 cites W4234401654 @default.
• W2624659504 cites W576069298 @default.
• W2624659504 cites W2572629854 @default.
• W2624659504 doi "https://doi.org/10.1016/j.cbpc.2017.06.001" @default.
• W2624659504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28602911" @default.
• W2624659504 hasPublicationYear "2017" @default.
• W2624659504 type Work @default.
• W2624659504 sameAs 2624659504 @default.
• W2624659504 citedByCount "7" @default.
• W2624659504 countsByYear W26246595042020 @default.
• W2624659504 countsByYear W26246595042021 @default.
• W2624659504 crossrefType "journal-article" @default.
• W2624659504 hasAuthorship W2624659504A5007929872 @default.
• W2624659504 hasAuthorship W2624659504A5011293370 @default.
• W2624659504 hasAuthorship W2624659504A5022145074 @default.
• W2624659504 hasAuthorship W2624659504A5054035530 @default.
• W2624659504 hasAuthorship W2624659504A5072069366 @default.
• W2624659504 hasAuthorship W2624659504A5080713696 @default.
• W2624659504 hasAuthorship W2624659504A5081780210 @default.
• W2624659504 hasAuthorship W2624659504A5087252178 @default.
• W2624659504 hasBestOaLocation W26246595041 @default.
• W2624659504 hasConcept C136764020 @default.
• W2624659504 hasConcept C181199279 @default.
• W2624659504 hasConcept C2776110065 @default.
• W2624659504 hasConcept C2776490341 @default.
• W2624659504 hasConcept C2777612826 @default.
• W2624659504 hasConcept C2777622882 @default.
• W2624659504 hasConcept C2777625466 @default.
• W2624659504 hasConcept C2779281246 @default.
• W2624659504 hasConcept C41008148 @default.
• W2624659504 hasConcept C55493867 @default.
• W2624659504 hasConcept C59822182 @default.
• W2624659504 hasConcept C71928629 @default.
• W2624659504 hasConcept C86803240 @default.
• W2624659504 hasConceptScore W2624659504C136764020 @default.
• W2624659504 hasConceptScore W2624659504C181199279 @default.
• W2624659504 hasConceptScore W2624659504C2776110065 @default.
• W2624659504 hasConceptScore W2624659504C2776490341 @default.
• W2624659504 hasConceptScore W2624659504C2777612826 @default.
• W2624659504 hasConceptScore W2624659504C2777622882 @default.
• W2624659504 hasConceptScore W2624659504C2777625466 @default.
• W2624659504 hasConceptScore W2624659504C2779281246 @default.
• W2624659504 hasConceptScore W2624659504C41008148 @default.
• W2624659504 hasConceptScore W2624659504C55493867 @default.
• W2624659504 hasConceptScore W2624659504C59822182 @default.
• W2624659504 hasConceptScore W2624659504C71928629 @default.

• next