FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2624707987> ?p ?o ?g. }

• W2624707987 endingPage "1576" @default.
• W2624707987 startingPage "1566" @default.
• W2624707987 abstract "Semaphorins are an essential family of guidance cues ubiquitously expressed in various organs, which play diverse developmental, homeostatic, and pathological roles. Semaphorin 3E (Sema3E), initially identified as a neuronal chemorepellent, is involved in the regulation of cell migration, proliferation, and angiogenesis. However, expression and function of Sema3E in allergic asthma has not been extensively investigated. We determined the expression of Sema3E in the airways and its effect on airway inflammation, hyperresponsiveness, and remodeling as pathological features of allergic asthma provoked by house dust mite in vivo. Our data indicate that exposure to house dust mite markedly reduces Sema3E expression in mouse airways. More important, replenishment of Sema3E by intranasal administration of exogenous Sema3E protects mice from allergic asthma by reducing eosinophilic inflammation, serum IgE level, and T helper cell 2/T helper cell 17 cytokine response. The regulatory effect of Sema3E on cytokine response was sustained on allergen recall response in the lymph nodes and spleen. Furthermore, goblet cell hyperplasia, collagen deposition, and airway hyperresponsiveness were significantly diminished on Sema3E treatment. The inhibitory effect of Sema3E was associated with a reduction of pulmonary CD11b+ conventional dendritic cells and regulation of CD4+ T-cell cytokine response. Collectively, our data represent a novel approach to treating allergic asthma via regulation of immune response to house dust mite." @default.
• W2624707987 created "2017-06-23" @default.
• W2624707987 creator A5004657168 @default.
• W2624707987 creator A5005217750 @default.
• W2624707987 creator A5044619429 @default.
• W2624707987 creator A5056432095 @default.
• W2624707987 creator A5059048178 @default.
• W2624707987 creator A5074779002 @default.
• W2624707987 date "2017-07-01" @default.
• W2624707987 modified "2023-10-03" @default.
• W2624707987 title "Semaphorin 3E Alleviates Hallmarks of House Dust Mite–Induced Allergic Airway Disease" @default.
• W2624707987 cites W1497452942 @default.
• W2624707987 cites W1865263763 @default.
• W2624707987 cites W1970463288 @default.
• W2624707987 cites W1986778052 @default.
• W2624707987 cites W1988387392 @default.
• W2624707987 cites W1993419066 @default.
• W2624707987 cites W1998850459 @default.
• W2624707987 cites W2003432505 @default.
• W2624707987 cites W2007713041 @default.
• W2624707987 cites W2016326804 @default.
• W2624707987 cites W2036472115 @default.
• W2624707987 cites W2044450879 @default.
• W2624707987 cites W2047804274 @default.
• W2624707987 cites W2048935137 @default.
• W2624707987 cites W2051049597 @default.
• W2624707987 cites W2055510343 @default.
• W2624707987 cites W2061435251 @default.
• W2624707987 cites W2061911569 @default.
• W2624707987 cites W2066266627 @default.
• W2624707987 cites W2071066049 @default.
• W2624707987 cites W2080317016 @default.
• W2624707987 cites W2087055962 @default.
• W2624707987 cites W2092836519 @default.
• W2624707987 cites W2103153413 @default.
• W2624707987 cites W2103229728 @default.
• W2624707987 cites W2108919922 @default.
• W2624707987 cites W2115232380 @default.
• W2624707987 cites W2120203591 @default.
• W2624707987 cites W2120821168 @default.
• W2624707987 cites W2123388791 @default.
• W2624707987 cites W2125267020 @default.
• W2624707987 cites W2133715809 @default.
• W2624707987 cites W2142495381 @default.
• W2624707987 cites W2143107468 @default.
• W2624707987 cites W2156822702 @default.
• W2624707987 cites W2160189724 @default.
• W2624707987 cites W2161594459 @default.
• W2624707987 cites W2165487188 @default.
• W2624707987 cites W2198108287 @default.
• W2624707987 cites W2341117108 @default.
• W2624707987 cites W2509564619 @default.
• W2624707987 cites W2537300122 @default.
• W2624707987 cites W2542516516 @default.
• W2624707987 cites W2552803697 @default.
• W2624707987 cites W2560826436 @default.
• W2624707987 cites W2575598859 @default.
• W2624707987 cites W2577698099 @default.
• W2624707987 cites W2582652923 @default.
• W2624707987 doi "https://doi.org/10.1016/j.ajpath.2017.03.008" @default.
• W2624707987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28634005" @default.
• W2624707987 hasPublicationYear "2017" @default.
• W2624707987 type Work @default.
• W2624707987 sameAs 2624707987 @default.
• W2624707987 citedByCount "29" @default.
• W2624707987 countsByYear W26247079872017 @default.
• W2624707987 countsByYear W26247079872018 @default.
• W2624707987 countsByYear W26247079872019 @default.
• W2624707987 countsByYear W26247079872020 @default.
• W2624707987 countsByYear W26247079872021 @default.
• W2624707987 countsByYear W26247079872022 @default.
• W2624707987 countsByYear W26247079872023 @default.
• W2624707987 crossrefType "journal-article" @default.
• W2624707987 hasAuthorship W2624707987A5004657168 @default.
• W2624707987 hasAuthorship W2624707987A5005217750 @default.
• W2624707987 hasAuthorship W2624707987A5044619429 @default.
• W2624707987 hasAuthorship W2624707987A5056432095 @default.
• W2624707987 hasAuthorship W2624707987A5059048178 @default.
• W2624707987 hasAuthorship W2624707987A5074779002 @default.
• W2624707987 hasBestOaLocation W26247079871 @default.
• W2624707987 hasConcept C126322002 @default.
• W2624707987 hasConcept C132538176 @default.
• W2624707987 hasConcept C170493617 @default.
• W2624707987 hasConcept C191732599 @default.
• W2624707987 hasConcept C203014093 @default.
• W2624707987 hasConcept C207480886 @default.
• W2624707987 hasConcept C2776914184 @default.
• W2624707987 hasConcept C2778166374 @default.
• W2624707987 hasConcept C2778690821 @default.
• W2624707987 hasConcept C2780510475 @default.
• W2624707987 hasConcept C32046619 @default.
• W2624707987 hasConcept C71924100 @default.
• W2624707987 hasConcept C86803240 @default.
• W2624707987 hasConceptScore W2624707987C126322002 @default.
• W2624707987 hasConceptScore W2624707987C132538176 @default.
• W2624707987 hasConceptScore W2624707987C170493617 @default.
• W2624707987 hasConceptScore W2624707987C191732599 @default.
• W2624707987 hasConceptScore W2624707987C203014093 @default.

• next