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- W2624725439 abstract "Floating microspheres prepared with enteric coated polymer successfully by the solvent diffusion method. Upon incorporation of the hydrophilic polymer such as HPMC in the shell of microspheres, the amount of drug release form microspheres could enhance. In vitro data obtained from floating microspheres of show Atenolol excellent float ability, good buoyancy and prolonged drug release. Floating microspheres different size and drug content could be obtained by varying formulation variable. Diffusion found to be the main release mechanisms. Thus the prepared floating microspheres may prove to be potential candidate for multiple-unit delivery device adaptable to any intra gastric condition. The formulations were evaluated for various Micromeritic and characteristic studies. It increases the bioavailability dosage form with prolonged effect, hence improve the patient compliance. Ideal property of floating microspheres includes high buoyancy and sufficient release rate of drug. It is necessary to selected appropriate balance between buoyancy and release rate drug from all developing floating microspheres. F4formulation showed the best appropriate balance between buoyancy and release rate drug, which can be considered as a best fit floating microspheres. The designed system F4 floats in the stomach and prolonged the gastric residence time (GIT) providing sustained release action, in addition floating microspheres enable to increase the absorption rate, as it gradually sank in the stomach and arrived at the absorption site. The developed formulation overcomes the drawback limitation of sustained release preparation. Therefore multiple units floating system i.e., floating microspheres will be possibly beneficial for sustained action. Key words: Microsphere Polymer, Atenolol, floating microspheres" @default.
- W2624725439 created "2017-06-23" @default.
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- W2624725439 date "2015-09-28" @default.
- W2624725439 modified "2023-09-23" @default.
- W2624725439 title "FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF ATENOLOL" @default.
- W2624725439 hasPublicationYear "2015" @default.
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