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• W2624771279 abstract "The median age of diagnosis of primary sclerosing cholangitis (PSC) is ∼30-40 years.We aimed to analyse disease progression and liver-dependent survival in patients diagnosed with PSC after 50 years of age.Patients with PSC were analysed with regard to their age at diagnosis. Patients with a first diagnosis of PSC after the age of 50 years were considered as the late-onset group.A total of 32/215 (14.9%) patients were diagnosed with PSC after 50 years of age. The proportion of females was significantly higher among patients with late-onset PSC (48.4 vs. 27.3%; p = 0.02). Patients with later diagnosis required dilatation therapy more often due to dominant stenosis (84.2 vs. 53.1%; p = 0.01) and suffered from recurrent cholangitis more often (48.3 vs. 21.0%; p = 0.003). Patients with late-onset PSC had reduced transplantation-free survival (10.5 ± 0.6 years vs. 20.8 ± 1.7 years, p < 0.0001), with progredient liver failure and cholangiocarcinoma as the leading causes of death.Patients with later age at diagnosis of PSC displayed a different clinical phenotype with a different sex ratio, immune status and an increased risk for progressive liver failure and biliary malignancies." @default.
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• W2624771279 date "2018-03-01" @default.
• W2624771279 modified "2023-09-25" @default.
• W2624771279 title "Impact of age at diagnosis on disease progression in patients with primary sclerosing cholangitis" @default.
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• W2624771279 doi "https://doi.org/10.1177/2050640617717156" @default.
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