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- W2624861490 abstract "Disturbed homeostasis as a result of tissue stress can provoke leukocyte responses enabling recovery. Since mild hypothermia displays specific clinically relevant tissue-protective properties and interleukin (IL)-22 promotes healing at host/environment interfaces, effects of lowered ambient temperature on IL-22 were studied. We demonstrate that a 5-h exposure of endotoxemic mice to 4°C reduces body temperature by 5.0° and enhances splenic and colonic il22 gene expression. In contrast, tumor necrosis factor-α and IL-17A were not increased. In vivo data on IL-22 were corroborated using murine splenocytes and human peripheral blood mononuclear cells (PBMC) cultured upon 33°C and polyclonal T cell activation. Upregulation by mild hypothermia of largely T-cell-derived IL-22 in PBMC required monocytes and associated with enhanced nuclear T-cell nuclear factor of activated T cells (NFAT)-c2. Notably, NFAT antagonism by cyclosporin A or FK506 impaired IL-22 upregulation at normothermia and entirely prevented its enhanced expression upon hypothermic culture conditions. Data suggest that intact NFAT signaling is required for efficient IL-22 induction upon normothermic and hypothermic conditions. Hypothermia furthermore boosted early signal transducer and activator of transcription 3 activation by IL-22 and shaped downstream gene expression in epithelial-like cells. Altogether, data indicate that hypothermia supports and fine-tunes IL-22 production/action, which may contribute to regulatory properties of low ambient temperature." @default.
- W2624861490 created "2017-06-23" @default.
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- W2624861490 date "2017-06-29" @default.
- W2624861490 modified "2023-10-03" @default.
- W2624861490 title "Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity" @default.
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- W2624861490 doi "https://doi.org/10.3389/fimmu.2017.00742" @default.
- W2624861490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5489602" @default.
- W2624861490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28706520" @default.
- W2624861490 hasPublicationYear "2017" @default.
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