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- W2625060734 abstract "BackgroundWe sought to clarify the effect of donor age as a continuous variable on morbidity and mortality in a single-institution experience.MethodsFrom 1986 to 2016, 882 adult lung transplants were performed, including 396 in the lung allocation score era. Kaplan-Meier curves and Cox proportional hazards models were used to evaluate the association of donor age with overall survival and bronchiolitis obliterans syndrome (BOS) score ≥1-free survival. Logistic regression was used to evaluate the association with primary graft dysfunction grade 3. Natural cubic splines were used to explore donor age in a continuous fashion to allow for nonlinear relationships.ResultsIn the lung allocation score era, unadjusted 5-year survival was not significantly different between 3 a priori–defined donor age groups: age <40, 40 to 54, and age ≥55 years (64%, 61%, and 69%, P = .8). Unadjusted 5-year freedom from BOS ≥1 was not significantly different (34%, 20%, and 33%, respectively, P = .1). After we adjusted for comorbidities, cubic spline analysis demonstrated no effect between donor age as a continuous variable and hazard for mortality at 5 years. Similarly, no interaction was seen between donor age and risk of BOS or primary graft dysfunction 3. Adjusted analysis of all 882 transplants pre- and postinception of the lung allocation score also showed no effect of age on 10-year survival.ConclusionsLong-term survival of lung transplant recipients was not affected by the age of the donor. These findings support the notion that donor age could be relaxed." @default.
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- W2625060734 date "2017-12-01" @default.
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- W2625060734 title "Clinical implications of donor age: A single-institution analysis spanning 3 decades" @default.
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- W2625060734 doi "https://doi.org/10.1016/j.jtcvs.2017.06.029" @default.
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