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- W2625117911 endingPage "780" @default.
- W2625117911 startingPage "766" @default.
- W2625117911 abstract "Lung malignancy is the foremost cause of cancer-related deaths globally and is frequently related to long-term tobacco smoking. Recent studies reveal that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared with non-malignant lung tissue. MMPs are zinc-dependent proteases and are involved in the degradation of extracellular matrix (ECM). Several investigations have shown that MMPs manipulate the activity of non-ECM molecules, including cytokines, growth factors and receptors that control the tumor microenvironment. In this review, we have summarized and critically reviewed the published works on the role of MMPs in non-small-cell lung cancer. We have also explored the structure of MMPs, their various types and roles in lung cancer metastasis including invasion, migration and angiogenesis." @default.
- W2625117911 created "2017-06-23" @default.
- W2625117911 creator A5020063441 @default.
- W2625117911 creator A5022827643 @default.
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- W2625117911 creator A5060577741 @default.
- W2625117911 creator A5069985051 @default.
- W2625117911 creator A5072400026 @default.
- W2625117911 creator A5079121504 @default.
- W2625117911 date "2017-06-16" @default.
- W2625117911 modified "2023-10-17" @default.
- W2625117911 title "Matrix metalloproteinases: their functional role in lung cancer" @default.
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