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- W2625179621 abstract "Determining the impact of lipid electrophile-mediated protein damage that occurs during oxidative stress requires a comprehensive analysis of electrophile targets adducted under pathophysiological conditions. Incorporation of ω-alkynyl linoleic acid into the phospholipids of macrophages prior to activation by Kdo2-lipid A, followed by protein extraction, click chemistry, and streptavidin affinity capture, enabled a systems-level survey of proteins adducted by lipid electrophiles generated endogenously during the inflammatory response. Results revealed a dramatic enrichment for membrane and mitochondrial proteins as targets for adduction. A marked decrease in adduction in the presence of MitoTEMPO demonstrated a primary role for mitochondrial superoxide in electrophile generation and indicated an important role for mitochondria as both a source and target of lipid electrophiles, a finding that has not been revealed by prior studies using exogenously provided electrophiles." @default.
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- W2625179621 date "2017-06-28" @default.
- W2625179621 modified "2023-09-25" @default.
- W2625179621 title "Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target" @default.
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- W2625179621 doi "https://doi.org/10.1021/acschembio.7b00480" @default.
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