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• W2625208045 startingPage "337" @default.
• W2625208045 abstract "Recurrent driver mutations in the genes encoding histones have been recently described in pediatric brain tumors, as well as in chondroblastomas and giant cell tumors of the bone. The mutations are often heterozygous and frequently comprise single amino acid substitutions in the tails of histone variants. Substitutions of methionine to lysine on H3.3K27 or H3.3K36 are the most common alterations, occurring in diffuse intrinsic pontine gliomas (DIPGs) and chondroblastomas, respectively. Current data suggest that histone mutations alter the epigenetic landscape in tumor cells and lead to a blockade of differentiation, but the mechanisms underlying oncogenesis are not fully understood. These mutations also exhibit a propensity for exclusive expression in specific cell lineages and, in the case of brain tumors, a remarkable anatomic and developmental specificity. The histone mutations have raised interest in promising novel therapeutic strategies that incorporate epigenetic drugs." @default.
• W2625208045 created "2017-06-23" @default.
• W2625208045 creator A5051203146 @default.
• W2625208045 creator A5081823120 @default.
• W2625208045 date "2018-03-04" @default.
• W2625208045 modified "2023-10-17" @default.
• W2625208045 title "Histone Mutations in Cancer" @default.
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• W2625208045 doi "https://doi.org/10.1146/annurev-cancerbio-030617-050143" @default.
• W2625208045 hasPublicationYear "2018" @default.
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