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- W2625392217 abstract "GPR55, a G protein-coupled receptor, is an attractive target to alleviate inflammatory and neuropathic pain and treat osteoporosis and cancer. Identifying a potent and selective ligand will aid to further establish the specific physiological roles and pharmacology of the receptor. Towards this goal, a targeted library of 22 compounds was synthesized in a modular fashion to obtain structure-activity relationship information. The general route consisted of coupling a variety of p-aminophenyl sulfonamides to isothiocyanates to form acylthioureas. For the synthesis of a known naphthyl ethyl alcohol motif, route modification led to a shorter and more efficient process. The 22 analogues were analyzed for their ability to serve as agonists at GPR55 and valuable information for both ends of the molecule was ascertained." @default.
- W2625392217 created "2017-06-23" @default.
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- W2625392217 date "2017-08-01" @default.
- W2625392217 modified "2023-10-13" @default.
- W2625392217 title "Design, synthesis and biological evaluation of GPR55 agonists" @default.
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- W2625392217 doi "https://doi.org/10.1016/j.bmc.2017.06.016" @default.
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