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• W2625575897 abstract "Multiple signaling pathways guide the behavior and differentiation of both germline stem cells (GSCs) and somatic stem cells (FSCs) in the Drosophila germarium, necessitating careful control of signal generation, range and responses. Signal integration involves Escort Cells (ECs), which promote differentiation of the GSC derivatives they envelop, provide niche signals for FSCs and derive directly from FSCs in adults. Hedgehog (Hh) signaling induces the Hippo pathway effector Yorkie (Yki) to promote proliferation and maintenance of FSCs but Hh also signals to ECs, which are quiescent. Here we show that in ECs both Hh and Yki limit production of BMP ligands to allow germline differentiation. Loss of Yki produced a more severe germarial phenotype than loss of Hh signaling and principally induced a different BMP ligand. Moreover, Yki activity reporters and epistasis tests showed that Yki does not mediate the key actions of Hh signaling in ECs. Thus, both the coupling and output of Hh and Yki signaling pathways differ between FSCs and ECs despite their proximity and the fact that FSCs give rise directly to ECs." @default.
• W2625575897 created "2017-06-23" @default.
• W2625575897 creator A5047919909 @default.
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• W2625575897 date "2017-01-01" @default.
• W2625575897 modified "2023-10-02" @default.
• W2625575897 title "Yorkie and Hedgehog independently restrict BMP production in Escort cells to permit germline differentiation in the Drosophila ovary" @default.
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• W2625575897 doi "https://doi.org/10.1242/dev.147702" @default.
• W2625575897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5536926" @default.
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