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• W2625594676 abstract "Abstract In the world of translational biomarkers, the bar is high for qualification of improved indicators of liver injury. A ‘holy grail’ of translational biomarkers with respect to drug-induced liver injury (DILI) will be the discovery, evaluation, and qualification of those that provide accurate prognoses regarding individuals that will go on to experience liver failure from those that recover given modest increases in ALT, AST and total bilirubin (TBL). The performance of these well-established liver function tests (LFT) is quite good in terms of sensitivity for diagnosing liver injury, but opportunities exist for developing specific indicators of injury and better prognostic biomarkers of liver failure. Presently, in the absence of novel qualified translational biomarkers, the challenge for drug discovery is to minimize, and ideally eliminate, late stage drug failures due to DILI signals that may or may not indicate life threatening injury. This will be achieved through the application of novel in vitro and in vivo models utilized early in the drug development process. Predictive structure activity relationship (SAR) models are being developed by leveraging data from these novel tools with clinical outcomes. Mechanistic insights to the underlying biological processes that initiate adverse clinical DILI are being elucidated and used to design better molecules with a higher probability of success while decreasing cost and time to market. In addition to the near term gains of acquiring these mechanistic insights, this enhanced understanding could result in novel translational biomarkers with improved diagnostic and prognostic power over ALT/AST and TBL alone resulting in safer drugs while ensuring patient safety." @default.
• W2625594676 created "2017-06-23" @default.
• W2625594676 creator A5005653591 @default.
• W2625594676 creator A5088375934 @default.
• W2625594676 date "2017-06-01" @default.
• W2625594676 modified "2023-09-27" @default.
• W2625594676 title "Derisking drug-induced liver injury from bench to bedside" @default.
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• W2625594676 cites W1822627299 @default.
• W2625594676 cites W1829584362 @default.
• W2625594676 cites W1850985451 @default.
• W2625594676 cites W1897615258 @default.
• W2625594676 cites W1973562229 @default.
• W2625594676 cites W1979002038 @default.
• W2625594676 cites W1979601962 @default.
• W2625594676 cites W1999869217 @default.
• W2625594676 cites W2000069042 @default.
• W2625594676 cites W2003673908 @default.
• W2625594676 cites W2006827135 @default.
• W2625594676 cites W2014830013 @default.
• W2625594676 cites W2019826921 @default.
• W2625594676 cites W2021513482 @default.
• W2625594676 cites W2030156043 @default.
• W2625594676 cites W2035459829 @default.
• W2625594676 cites W2037199469 @default.
• W2625594676 cites W2037335878 @default.
• W2625594676 cites W2040624227 @default.
• W2625594676 cites W2044498526 @default.
• W2625594676 cites W2047718984 @default.
• W2625594676 cites W2054546147 @default.
• W2625594676 cites W2055162008 @default.
• W2625594676 cites W2061817855 @default.
• W2625594676 cites W2067114856 @default.
• W2625594676 cites W2072702283 @default.
• W2625594676 cites W2075352120 @default.
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• W2625594676 cites W2083820537 @default.
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• W2625594676 cites W2140099006 @default.
• W2625594676 cites W2140962831 @default.
• W2625594676 cites W2151666851 @default.
• W2625594676 cites W2153804622 @default.
• W2625594676 cites W2159701371 @default.
• W2625594676 cites W2172564131 @default.
• W2625594676 cites W2175940079 @default.
• W2625594676 cites W2176645803 @default.
• W2625594676 cites W2231409040 @default.
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• W2625594676 cites W2587060928 @default.
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• W2625594676 cites W65856228 @default.
• W2625594676 cites W78193575 @default.
• W2625594676 doi "https://doi.org/10.1016/j.cotox.2017.06.006" @default.
• W2625594676 hasPublicationYear "2017" @default.
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