Matches in SemOpenAlex for { <https://semopenalex.org/work/W2625596381> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2625596381 abstract "The molecular mechanisms by which floral homeotic genes act as major developmental switches to specify the identity of floral organs, are still largely unknown. Floral homeotic genes encode transcription factors of the MADS-box family, which are supposed to assemble in a combinatorial fashion into organ-specific multimeric protein complexes. Major mediators of protein interactions are MADS-domain proteins of the SEPALLATA subfamily, which play a crucial role in the development of all types of floral organs. In order to characterize the roles of the SEPALLATA3 transcription factor complexes at the molecular level, we analyzed genome-wide the direct targets of SEPALLATA3. We used chromatin immunoprecipitation followed by ultrahigh-throughput sequencing or hybridization to whole-genome tiling arrays to obtain genome-wide DNA-binding patterns of SEPALLATA3. The results demonstrate that SEPALLATA3 binds to thousands of sites in the genome. Most potential target sites that were strongly bound in wild-type inflorescences, are also bound in the floral homeotic agamous mutant, which displays only the perianth organs, sepals and petals. Characterization of the target genes shows that SEPALLATA3 integrates and modulates different growth-related and hormonal pathways in a combinatorial fashion with other MADS-box proteins and possibly with non-MADS transcription factors. In particular, the results suggest multiple links between SEPALLATA3 and auxin signaling pathways. Our gene expression analyses link the genomic binding site data with the phenotype of plants expressing a dominant repressor version of SEPALLATA3, suggesting that it modulates auxin response to facilitate floral organ outgrowth and morphogenesis. Furthermore, the binding of the SEPALLATA3 protein to cis-regulatory elements of other MADS-box genes and expression analyses reveal that this protein is a key component in the regulatory transcriptional network underlying the formation of floral organs." @default.
- W2625596381 created "2017-06-23" @default.
- W2625596381 creator A5004592733 @default.
- W2625596381 creator A5013607769 @default.
- W2625596381 creator A5015518153 @default.
- W2625596381 creator A5026936618 @default.
- W2625596381 creator A5051914912 @default.
- W2625596381 creator A5078998093 @default.
- W2625596381 creator A5081125994 @default.
- W2625596381 date "2009-01-01" @default.
- W2625596381 modified "2023-09-27" @default.
- W2625596381 title "Target genes of the MADS transcription factor SEPALLATA3, ChIP-seq" @default.
- W2625596381 hasPublicationYear "2009" @default.
- W2625596381 type Work @default.
- W2625596381 sameAs 2625596381 @default.
- W2625596381 citedByCount "0" @default.
- W2625596381 crossrefType "journal-article" @default.
- W2625596381 hasAuthorship W2625596381A5004592733 @default.
- W2625596381 hasAuthorship W2625596381A5013607769 @default.
- W2625596381 hasAuthorship W2625596381A5015518153 @default.
- W2625596381 hasAuthorship W2625596381A5026936618 @default.
- W2625596381 hasAuthorship W2625596381A5051914912 @default.
- W2625596381 hasAuthorship W2625596381A5078998093 @default.
- W2625596381 hasAuthorship W2625596381A5081125994 @default.
- W2625596381 hasConcept C101762097 @default.
- W2625596381 hasConcept C104317684 @default.
- W2625596381 hasConcept C111936080 @default.
- W2625596381 hasConcept C121587040 @default.
- W2625596381 hasConcept C134320426 @default.
- W2625596381 hasConcept C13512557 @default.
- W2625596381 hasConcept C141231307 @default.
- W2625596381 hasConcept C143065580 @default.
- W2625596381 hasConcept C150194340 @default.
- W2625596381 hasConcept C160956161 @default.
- W2625596381 hasConcept C18903297 @default.
- W2625596381 hasConcept C2778456059 @default.
- W2625596381 hasConcept C2779491563 @default.
- W2625596381 hasConcept C2780618852 @default.
- W2625596381 hasConcept C29172406 @default.
- W2625596381 hasConcept C46751350 @default.
- W2625596381 hasConcept C54355233 @default.
- W2625596381 hasConcept C86339819 @default.
- W2625596381 hasConcept C86803240 @default.
- W2625596381 hasConceptScore W2625596381C101762097 @default.
- W2625596381 hasConceptScore W2625596381C104317684 @default.
- W2625596381 hasConceptScore W2625596381C111936080 @default.
- W2625596381 hasConceptScore W2625596381C121587040 @default.
- W2625596381 hasConceptScore W2625596381C134320426 @default.
- W2625596381 hasConceptScore W2625596381C13512557 @default.
- W2625596381 hasConceptScore W2625596381C141231307 @default.
- W2625596381 hasConceptScore W2625596381C143065580 @default.
- W2625596381 hasConceptScore W2625596381C150194340 @default.
- W2625596381 hasConceptScore W2625596381C160956161 @default.
- W2625596381 hasConceptScore W2625596381C18903297 @default.
- W2625596381 hasConceptScore W2625596381C2778456059 @default.
- W2625596381 hasConceptScore W2625596381C2779491563 @default.
- W2625596381 hasConceptScore W2625596381C2780618852 @default.
- W2625596381 hasConceptScore W2625596381C29172406 @default.
- W2625596381 hasConceptScore W2625596381C46751350 @default.
- W2625596381 hasConceptScore W2625596381C54355233 @default.
- W2625596381 hasConceptScore W2625596381C86339819 @default.
- W2625596381 hasConceptScore W2625596381C86803240 @default.
- W2625596381 hasLocation W26255963811 @default.
- W2625596381 hasOpenAccess W2625596381 @default.
- W2625596381 hasPrimaryLocation W26255963811 @default.
- W2625596381 hasRelatedWork W2031795488 @default.
- W2625596381 hasRelatedWork W2033517505 @default.
- W2625596381 hasRelatedWork W2052592338 @default.
- W2625596381 hasRelatedWork W2056228546 @default.
- W2625596381 hasRelatedWork W2078747810 @default.
- W2625596381 hasRelatedWork W2102274738 @default.
- W2625596381 hasRelatedWork W2103454945 @default.
- W2625596381 hasRelatedWork W2107454064 @default.
- W2625596381 hasRelatedWork W2129032632 @default.
- W2625596381 hasRelatedWork W2135096257 @default.
- W2625596381 hasRelatedWork W2145958708 @default.
- W2625596381 hasRelatedWork W2155585326 @default.
- W2625596381 hasRelatedWork W2187693404 @default.
- W2625596381 hasRelatedWork W2402353156 @default.
- W2625596381 hasRelatedWork W2469427702 @default.
- W2625596381 hasRelatedWork W2633095038 @default.
- W2625596381 hasRelatedWork W2952392117 @default.
- W2625596381 hasRelatedWork W3164297023 @default.
- W2625596381 hasRelatedWork W6357707 @default.
- W2625596381 hasRelatedWork W2182431827 @default.
- W2625596381 isParatext "false" @default.
- W2625596381 isRetracted "false" @default.
- W2625596381 magId "2625596381" @default.
- W2625596381 workType "article" @default.