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- W2625700413 abstract "Abstract : Our understanding of the cellular and molecular mechanisms underlying adult neurogenesis in response to diseases of the CNS is incomplete. Decreased neurogenesis in the adult hippocampus in response to stressors is well established in rodent and nonhuman primate models of depression. Recently, increased neurogenesis has been linked to the actions of certain antidepressants, including tranylcypromine (TCP) in the treatment of depression. The goldfish (Carassius auratus) has the ability to grow its body and brain throughout its life and is an ideal model for studying adult neurogenesis. The hypothesis was that alterations in adult goldfish proliferation zones can be used to determine antidepressant effects on proliferation. Three specific aims were used to test this hypothesis: 1) To produce an atlas of the goldfish brain based on cresyl violet stained sections. 2) To construct an atlas of proliferation zones the goldfish brain. 3) To study the influence of the antidepressant tranylcypromine on progenitor cell proliferation zones in the telencephalon, optic tectum, and cerebellum of adult goldfish." @default.
- W2625700413 created "2017-06-23" @default.
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- W2625700413 date "2007-07-27" @default.
- W2625700413 modified "2023-09-24" @default.
- W2625700413 title "Evaluation of the Adult Goldfish Brain as a Model for the Study of Progenitor Cells" @default.
- W2625700413 doi "https://doi.org/10.21236/ad1014061" @default.
- W2625700413 hasPublicationYear "2007" @default.
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