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• W2625733228 endingPage "648" @default.
• W2625733228 startingPage "624" @default.
• W2625733228 abstract "Most neurodegenerative disorders (NDDs) are characterized by cognitive impairment and other neurological defects. The definite cause of and pathways underlying the progression of these NDDs are not well-defined. Several mechanisms have been proposed to contribute to the development of NDDs. These mechanisms may proceed concurrently or successively, and they differ among cell types at different developmental stages in distinct brain regions. The endocannabinoid system, which involves cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), endogenous cannabinoids and the enzymes that catabolize these compounds, has been shown to contribute to the development of NDDs in several animal models and human studies. In this review, we discuss the functions of the endocannabinoid system in NDDs and converse the therapeutic efficacy of targeting the endocannabinoid system to rescue NDDs." @default.
• W2625733228 created "2017-06-23" @default.
• W2625733228 creator A5040920903 @default.
• W2625733228 creator A5041051861 @default.
• W2625733228 creator A5076927867 @default.
• W2625733228 creator A5090334436 @default.
• W2625733228 date "2017-07-05" @default.
• W2625733228 modified "2023-10-12" @default.
• W2625733228 title "Endocannabinoid system in neurodegenerative disorders" @default.
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