Matches in SemOpenAlex for { <https://semopenalex.org/work/W2625771490> ?p ?o ?g. }
- W2625771490 abstract "Astrocytes are the most abundant glial cell type in the central nervous system (CNS) and are known to fulfill critical homeostatic functions. Dysfunction of activated astrocytes is also known to participate in the development of several neurological diseases. Astrocytes can be uniquely identified by expression of the intermediate filament protein glial acidic fibrillary protein (GFAP). Herein, we report on the development of a rigorous and sensitive methodology to identify GFAP+ exosomes in primary culture using flow cytometry. We then demonstrate that activated astrocytes release increased amounts of exosomes in response to treatment with interleukin-1β. Using this methodology, we report the identification of GFAP+ exosomes in blood and then use a mouse model of inflammatory demyelination, experimental autoimmune encephalomyelitis (EAE), to examine whether the abundance of GFAP+ exosomes in blood circulation changes during clinical illness. We find a detectable increase in the presence of GFAP+ exosomes in EAE mice when compared with non-EAE, control mice. Our data provide a novel perspective on the presence of GFAP in blood as it identifies exosomes as potential astrocyte-derived signals within blood. These data are complementary to previous clinical studies that reported elevated GFAP protein in blood samples from multiple sclerosis (MS) patients during a clinical relapse. These data also reveal the existence of a potential systemic role for astrocyte-derived exosomes in CNS conditions involving inflammation such as multiple sclerosis." @default.
- W2625771490 created "2017-06-23" @default.
- W2625771490 creator A5022984404 @default.
- W2625771490 creator A5027034727 @default.
- W2625771490 creator A5062060144 @default.
- W2625771490 creator A5063575170 @default.
- W2625771490 creator A5078028585 @default.
- W2625771490 creator A5091297985 @default.
- W2625771490 date "2017-06-15" @default.
- W2625771490 modified "2023-10-02" @default.
- W2625771490 title "A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma" @default.
- W2625771490 cites W1002209064 @default.
- W2625771490 cites W1480925601 @default.
- W2625771490 cites W151403426 @default.
- W2625771490 cites W1524589668 @default.
- W2625771490 cites W1529702627 @default.
- W2625771490 cites W1579103205 @default.
- W2625771490 cites W1834417670 @default.
- W2625771490 cites W1877235802 @default.
- W2625771490 cites W1895972767 @default.
- W2625771490 cites W1964282366 @default.
- W2625771490 cites W1967508251 @default.
- W2625771490 cites W1968527111 @default.
- W2625771490 cites W1972999695 @default.
- W2625771490 cites W1974954833 @default.
- W2625771490 cites W1979751563 @default.
- W2625771490 cites W1980444303 @default.
- W2625771490 cites W1980610697 @default.
- W2625771490 cites W1982850249 @default.
- W2625771490 cites W1983166842 @default.
- W2625771490 cites W1983283455 @default.
- W2625771490 cites W1983660498 @default.
- W2625771490 cites W1985458075 @default.
- W2625771490 cites W1987523416 @default.
- W2625771490 cites W1989975469 @default.
- W2625771490 cites W1990078383 @default.
- W2625771490 cites W1990195639 @default.
- W2625771490 cites W1993321996 @default.
- W2625771490 cites W2004550170 @default.
- W2625771490 cites W2004555438 @default.
- W2625771490 cites W2005312157 @default.
- W2625771490 cites W2005792762 @default.
- W2625771490 cites W2007106590 @default.
- W2625771490 cites W2007499410 @default.
- W2625771490 cites W2009662591 @default.
- W2625771490 cites W2015805487 @default.
- W2625771490 cites W2019589994 @default.
- W2625771490 cites W2021949049 @default.
- W2625771490 cites W2032055408 @default.
- W2625771490 cites W2033112925 @default.
- W2625771490 cites W2037655228 @default.
- W2625771490 cites W2039436205 @default.
- W2625771490 cites W2040481506 @default.
- W2625771490 cites W2041302454 @default.
- W2625771490 cites W2043661303 @default.
- W2625771490 cites W2048734728 @default.
- W2625771490 cites W2055313665 @default.
- W2625771490 cites W2057135010 @default.
- W2625771490 cites W2059355164 @default.
- W2625771490 cites W2061488553 @default.
- W2625771490 cites W2061739297 @default.
- W2625771490 cites W2065936039 @default.
- W2625771490 cites W2067673653 @default.
- W2625771490 cites W2074661552 @default.
- W2625771490 cites W2079670151 @default.
- W2625771490 cites W2084280740 @default.
- W2625771490 cites W2084887202 @default.
- W2625771490 cites W2085611469 @default.
- W2625771490 cites W2085656073 @default.
- W2625771490 cites W2086436146 @default.
- W2625771490 cites W2086722873 @default.
- W2625771490 cites W2089187494 @default.
- W2625771490 cites W2090044366 @default.
- W2625771490 cites W2090286349 @default.
- W2625771490 cites W2093877546 @default.
- W2625771490 cites W2093976723 @default.
- W2625771490 cites W2098259366 @default.
- W2625771490 cites W2098622411 @default.
- W2625771490 cites W2100927341 @default.
- W2625771490 cites W2101495492 @default.
- W2625771490 cites W2105531135 @default.
- W2625771490 cites W2107660300 @default.
- W2625771490 cites W2121588319 @default.
- W2625771490 cites W2121882633 @default.
- W2625771490 cites W2146546145 @default.
- W2625771490 cites W2155023773 @default.
- W2625771490 cites W2156281143 @default.
- W2625771490 cites W2156298828 @default.
- W2625771490 cites W2157378254 @default.
- W2625771490 cites W2162079087 @default.
- W2625771490 cites W2167844952 @default.
- W2625771490 cites W2184491519 @default.
- W2625771490 cites W2386409166 @default.
- W2625771490 cites W2557064274 @default.
- W2625771490 cites W2563075582 @default.
- W2625771490 cites W2563714496 @default.
- W2625771490 cites W2564702898 @default.
- W2625771490 cites W2572710398 @default.
- W2625771490 cites W4313341425 @default.
- W2625771490 doi "https://doi.org/10.3389/fnins.2017.00335" @default.