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- W2625782423 startingPage "160" @default.
- W2625782423 abstract "Tight and adherens junctions play critical roles in the barrier, adhesion, and signaling functions of epithelial and endothelial cells. How the molecular organization of these junctions is tuned to the widely diverse physiological requirements of each tissue type is not well understood. Here, we address this question by examining the expression, localization, and interactions of major cytoplasmic plaque proteins of tight and adherens junctions in different cultured epithelial and endothelial cell lines. Immunoblotting and immunofluorescence analyses show that the expression profiles of cingulin, paracingulin, ZO-1, ZO-2, ZO-3, PLEKHA7, afadin, PDZD11, p120-catenin, and α-catenin, as well as the transmembrane junctional proteins occludin, E-cadherin, and VE-cadherin, are significantly diverse when comparing kidney cells (MDCK, mCCD), keratinocytes (HaCaT), lung carcinoma (A427, A549), and endothelium-derived cells (bEnd.3, meEC, H5V). Proximity ligation and co-immunoprecipitation assays show that PLEKHA7 and PDZD11 are significantly more associated with the tight junction proteins cingulin and ZO-1 in aortic endothelium–derived (meEC) cells but not kidney collecting duct epithelial (mCCD) cells. These results provide evidence that the cytoplasmic plaques of tight and adherens junctions are diverse in their composition and molecular architecture and establish a conceptual framework by which we can rationally address the mechanisms of tissue-dependent junction physiology and signaling by cytoplasmic junctional proteins." @default.
- W2625782423 created "2017-06-23" @default.
- W2625782423 creator A5004434076 @default.
- W2625782423 creator A5022013696 @default.
- W2625782423 creator A5024526012 @default.
- W2625782423 creator A5056954886 @default.
- W2625782423 date "2017-06-15" @default.
- W2625782423 modified "2023-10-12" @default.
- W2625782423 title "Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions" @default.
- W2625782423 cites W118632756 @default.
- W2625782423 cites W1498982214 @default.
- W2625782423 cites W1608259439 @default.
- W2625782423 cites W1766182140 @default.
- W2625782423 cites W1840918758 @default.
- W2625782423 cites W1841412170 @default.
- W2625782423 cites W1854528864 @default.
- W2625782423 cites W1885525264 @default.
- W2625782423 cites W1929386789 @default.
- W2625782423 cites W1969434689 @default.
- W2625782423 cites W1972431425 @default.
- W2625782423 cites W1974195387 @default.
- W2625782423 cites W1976439848 @default.
- W2625782423 cites W1979549875 @default.
- W2625782423 cites W1980059877 @default.
- W2625782423 cites W1981004291 @default.
- W2625782423 cites W1981176734 @default.
- W2625782423 cites W1988146044 @default.
- W2625782423 cites W1988308292 @default.
- W2625782423 cites W1988883882 @default.
- W2625782423 cites W1992883702 @default.
- W2625782423 cites W1995022882 @default.
- W2625782423 cites W1996838055 @default.
- W2625782423 cites W1996902174 @default.
- W2625782423 cites W1999842957 @default.
- W2625782423 cites W2000422049 @default.
- W2625782423 cites W2001629081 @default.
- W2625782423 cites W2003572756 @default.
- W2625782423 cites W2006476951 @default.
- W2625782423 cites W2007154580 @default.
- W2625782423 cites W2011812152 @default.
- W2625782423 cites W2015102346 @default.
- W2625782423 cites W2016734187 @default.
- W2625782423 cites W2016753320 @default.
- W2625782423 cites W2022174383 @default.
- W2625782423 cites W2022219701 @default.
- W2625782423 cites W2024222737 @default.
- W2625782423 cites W2024726151 @default.
- W2625782423 cites W2028224423 @default.
- W2625782423 cites W2028514452 @default.
- W2625782423 cites W2032930150 @default.
- W2625782423 cites W2034057105 @default.
- W2625782423 cites W2036496674 @default.
- W2625782423 cites W2040645020 @default.
- W2625782423 cites W2041677910 @default.
- W2625782423 cites W2043249951 @default.
- W2625782423 cites W2044517944 @default.
- W2625782423 cites W2051326604 @default.
- W2625782423 cites W2051408959 @default.
- W2625782423 cites W2056318837 @default.
- W2625782423 cites W2056700437 @default.
- W2625782423 cites W2067045943 @default.
- W2625782423 cites W2071233660 @default.
- W2625782423 cites W2073543360 @default.
- W2625782423 cites W2076010055 @default.
- W2625782423 cites W2077340378 @default.
- W2625782423 cites W2078236511 @default.
- W2625782423 cites W2079966013 @default.
- W2625782423 cites W2081797711 @default.
- W2625782423 cites W2084123893 @default.
- W2625782423 cites W2091531773 @default.
- W2625782423 cites W2091677273 @default.
- W2625782423 cites W2092956762 @default.
- W2625782423 cites W2097466860 @default.
- W2625782423 cites W2098215722 @default.
- W2625782423 cites W2098455835 @default.
- W2625782423 cites W2100678115 @default.
- W2625782423 cites W2101379456 @default.
- W2625782423 cites W2102838769 @default.
- W2625782423 cites W2104567497 @default.
- W2625782423 cites W2105487832 @default.
- W2625782423 cites W2108109566 @default.
- W2625782423 cites W2109975931 @default.
- W2625782423 cites W2111245936 @default.
- W2625782423 cites W2111937069 @default.
- W2625782423 cites W2111964892 @default.
- W2625782423 cites W2113266085 @default.
- W2625782423 cites W2116946576 @default.
- W2625782423 cites W2118600419 @default.
- W2625782423 cites W2119516817 @default.
- W2625782423 cites W2123153844 @default.
- W2625782423 cites W2123230988 @default.
- W2625782423 cites W2128276650 @default.
- W2625782423 cites W2128826029 @default.
- W2625782423 cites W2132024007 @default.
- W2625782423 cites W2132375258 @default.
- W2625782423 cites W2143453317 @default.
- W2625782423 cites W2143464311 @default.
- W2625782423 cites W2143646667 @default.