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- W2625829876 endingPage "142" @default.
- W2625829876 startingPage "134" @default.
- W2625829876 abstract "The Androgen Receptor (AR), a member of the steroid hormone receptor family, plays important roles in the physiology and pathology of diverse tissues. AR ligands, which include circulating testosterone and locally synthesized dihydrotestosterone, bind to and activate the AR to elicit their effects. Ubiquitous expression of the AR, metabolism and cross reactivity with other receptors limit broad therapeutic utilization of steroidal androgens. However, the discovery of selective androgen receptor modulators (SARMs) and other tissue-selective nuclear hormone receptor modulators that activate their cognate receptors in a tissue-selective manner provides an opportunity to promote the beneficial effects of androgens and other hormones in target tissues with greatly reduced unwanted side-effects. In the last two decades, significant resources have been dedicated to the discovery and biological characterization of SARMs in an effort to harness the untapped potential of the AR. SARMs have been proposed as treatments of choice for various diseases, including muscle-wasting, breast cancer, and osteoporosis. This review provides insight into the evolution of SARMs from proof-of-concept agents to the cusp of therapeutic use in less than two decades, while covering contemporary views of their mechanisms of action and therapeutic benefits." @default.
- W2625829876 created "2017-06-23" @default.
- W2625829876 creator A5002243266 @default.
- W2625829876 creator A5047984092 @default.
- W2625829876 creator A5067659573 @default.
- W2625829876 date "2018-04-01" @default.
- W2625829876 modified "2023-10-16" @default.
- W2625829876 title "Development of selective androgen receptor modulators (SARMs)" @default.
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