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- W2625853094 abstract "Fundamental studies have identified a new group of gaseous signaling molecules – the so-called gasotransmitters – NO, CO, and H2S, which are involved in the regulation of a large number of metabolic processes. The results of these studies allowed determining a new direction in medicinal/pharmaceutical chemistry – creation of hydrogen sulfide donor compounds as potential drugs. The article presents the main achievements in the search for new H2S donors: the main stages of H2S metabolism and its biological effects; the classes of compounds that can release hydrogen sulfide based on the nature of sulfur-containing functional groups as well as the mechanism of H2S releasing. Additionally, the characteristic of the most successful direction – creation of the so-called hybrid molecules is given. The latter are compounds bearing fragments of the well known drugs covalently bounded with groups being capable to release H2S." @default.
- W2625853094 created "2017-06-23" @default.
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- W2625853094 date "2017-05-23" @default.
- W2625853094 modified "2023-09-25" @default.
- W2625853094 title "H2S Donors in creation of innovative drugs" @default.
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- W2625853094 doi "https://doi.org/10.24959/ophcj.17.918" @default.
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