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• W2625904071 abstract "Context.— Different types of mature B-cell lymphomas, including plasma cell neoplasms, exhibit distinct immunohistochemical profiles, which enable them to be correctly diagnosed. However, except for rare examples of lymphoma-specific immunohistochemistry, such as cyclin D1 in mantle cell lymphoma and annexin A1 in hairy cell leukemia, immunohistochemical profiles of mature B-cell lymphomas overlap and lack specificity. Objectives.— To systemically review immunohistochemical features associated with commonly encountered mature B-cell lymphomas based on the presence or absence of CD5 and CD10; to review the immunophenotypic profile of plasma cells derived from plasma cell myelomas and B-cell lymphomas; and to review a group of rare, aggressive B-cell lymphomas with antigen expression features of plasma cells. Data Sources.— Published and PubMed-indexed English literature was reviewed. Conclusions.— Although the presence or absence of CD5 and CD10 expression should be included in the initial immunohistochemistry screening panel for mature B-cell lymphomas, appropriate and judicial use of other B-cell antigens is necessary to ensure correct diagnoses. Furthermore, although the status of CD5 and CD10 expression is associated with certain prototypes of B-cell lymphomas, their expression is not specific. Plasma cells from plasma cell neoplasias and B-cell lymphomas exhibit overlapping but relatively distinct immunophenotypes; thus, a panel of immunohistochemical markers (CD19, CD45, CD56, and CD117) can be employed for their proper identification. Lastly, CD138 staining results are almost always positive in a group of aggressive B-cell lymphomas with plasmablastic features, including plasmablastic plasma cell myeloma, plasmablastic lymphoma, and ALK-1+ large B-cell lymphoma." @default.
• W2625904071 created "2017-06-23" @default.
• W2625904071 creator A5014096610 @default.
• W2625904071 creator A5064786948 @default.
• W2625904071 date "2017-06-13" @default.
• W2625904071 modified "2023-09-30" @default.
• W2625904071 title "Diagnostic Algorithm of Common Mature B-Cell Lymphomas by Immunohistochemistry" @default.
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• W2625904071 doi "https://doi.org/10.5858/arpa.2016-0521-ra" @default.
• W2625904071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28608720" @default.
• W2625904071 hasPublicationYear "2017" @default.
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