FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2625948944> ?p ?o ?g. }

• W2625948944 endingPage "546" @default.
• W2625948944 startingPage "536" @default.
• W2625948944 abstract "This study aims to elucidate the mechanisms by which microRNA-143-5p (miR-143-5p) targets runt-related transcription factor 2 (Runx2) in the differentiation of dental pulp stem cells (DPSCs) into odontoblasts, through regulating the osteoprotegerin receptor activator of the nuclear factor-κB ligand (OPG/RANKL) signaling pathway. Following transfection, DPSCs were divided into blank, control, miR-143-5p mimics, miR-143-5p inhibitors, miR-143-5p inhibitors + siRunx2 and siRunx2 groups. Alkaline phosphatase (ALP) activity and mineralized nodules were detected using ALP kit and alizarin red staining. Quantitative reverse transcriptase real time PCR (qRT-PCR) was conducted to measure mRNA expressions of miR-143-5p, Runx2, OPG, and RANKL. Western blotting was used to assess protein expression of odontoblast differentiation-related proteins. Transwell assay and an extracellular matrix (ECM) adhesion cell assay were employed to examine cell migration and cell adhesion. Compared with the blank group, the miR-143-5p mimics and siRunx2 groups showed decreased ALP activity, decreased mineralized nodules and displays of calcium. Fewer migrated cells, weakened cell adhesion, decreased protein expression of dentin phosphoprotein (DPP), dentin sialoprotein (DSP), dentin matrix protein 1 (DMP1), osteopontin (OPN), bone sialoprotein (BSP), osteocalcin (OCN), OPG and Runx2, and increased RANKL protein expressions were observed. Additionally, opposite results were observed in the miR-143-5p inhibitors group, demonstrating that down-regulated miR-143-5p promotes the differentiation of DPSCs into odontoblasts by enhancing Runx2 expression via the OPG/RANKL signaling pathway. Based on findings in this study, it is postulated that the enhancement of Runx2 expression via the regulation of the OPG/RANKL signaling pathway could be a beneficial approach for dental pulp regeneration. J. Cell. Biochem. 119: 536–546, 2018. © 2017 Wiley Periodicals, Inc." @default.
• W2625948944 created "2017-06-23" @default.
• W2625948944 creator A5002787785 @default.
• W2625948944 creator A5042389036 @default.
• W2625948944 creator A5086326351 @default.
• W2625948944 date "2017-07-24" @default.
• W2625948944 modified "2023-09-30" @default.
• W2625948944 title "<i>Retracted:</i> The Role of MicroRNA‐143‐5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting <i>Runx2</i> via the <i>OPG</i> / <i>RANKL</i> Signaling Pathway" @default.
• W2625948944 cites W1541230434 @default.
• W2625948944 cites W1550293405 @default.
• W2625948944 cites W1644648708 @default.
• W2625948944 cites W1666397465 @default.
• W2625948944 cites W1871697889 @default.
• W2625948944 cites W1954145299 @default.
• W2625948944 cites W1966565106 @default.
• W2625948944 cites W1975953388 @default.
• W2625948944 cites W1977180007 @default.
• W2625948944 cites W1988244669 @default.
• W2625948944 cites W1990639849 @default.
• W2625948944 cites W1996630410 @default.
• W2625948944 cites W2003004227 @default.
• W2625948944 cites W2008062102 @default.
• W2625948944 cites W2012849022 @default.
• W2625948944 cites W2020475710 @default.
• W2625948944 cites W2023520235 @default.
• W2625948944 cites W2033245629 @default.
• W2625948944 cites W2034381565 @default.
• W2625948944 cites W2041308307 @default.
• W2625948944 cites W2042960552 @default.
• W2625948944 cites W2050525149 @default.
• W2625948944 cites W2075356405 @default.
• W2625948944 cites W2104147425 @default.
• W2625948944 cites W2118864876 @default.
• W2625948944 cites W2128061107 @default.
• W2625948944 cites W2138284463 @default.
• W2625948944 cites W2139306163 @default.
• W2625948944 cites W2143489820 @default.
• W2625948944 cites W2147189505 @default.
• W2625948944 cites W2148892735 @default.
• W2625948944 cites W2150353046 @default.
• W2625948944 cites W2164847396 @default.
• W2625948944 cites W2166091458 @default.
• W2625948944 cites W2167775400 @default.
• W2625948944 cites W2168190946 @default.
• W2625948944 cites W2196479664 @default.
• W2625948944 cites W2374279538 @default.
• W2625948944 cites W2395672085 @default.
• W2625948944 cites W2406572795 @default.
• W2625948944 cites W2431574038 @default.
• W2625948944 cites W2435987423 @default.
• W2625948944 cites W2467373004 @default.
• W2625948944 cites W2474377732 @default.
• W2625948944 cites W2486758114 @default.
• W2625948944 cites W2509380984 @default.
• W2625948944 cites W2515532769 @default.
• W2625948944 cites W2529488649 @default.
• W2625948944 cites W2584265157 @default.
• W2625948944 doi "https://doi.org/10.1002/jcb.26212" @default.
• W2625948944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28608628" @default.
• W2625948944 hasPublicationYear "2017" @default.
• W2625948944 type Work @default.
• W2625948944 sameAs 2625948944 @default.
• W2625948944 citedByCount "31" @default.
• W2625948944 countsByYear W26259489442018 @default.
• W2625948944 countsByYear W26259489442019 @default.
• W2625948944 countsByYear W26259489442020 @default.
• W2625948944 countsByYear W26259489442021 @default.
• W2625948944 countsByYear W26259489442022 @default.
• W2625948944 countsByYear W26259489442023 @default.
• W2625948944 crossrefType "journal-article" @default.
• W2625948944 hasAuthorship W2625948944A5002787785 @default.
• W2625948944 hasAuthorship W2625948944A5042389036 @default.
• W2625948944 hasAuthorship W2625948944A5086326351 @default.
• W2625948944 hasBestOaLocation W26259489441 @default.
• W2625948944 hasConcept C104317684 @default.
• W2625948944 hasConcept C131075544 @default.
• W2625948944 hasConcept C142724271 @default.
• W2625948944 hasConcept C153911025 @default.
• W2625948944 hasConcept C160160445 @default.
• W2625948944 hasConcept C170493617 @default.
• W2625948944 hasConcept C181199279 @default.
• W2625948944 hasConcept C185592680 @default.
• W2625948944 hasConcept C188442228 @default.
• W2625948944 hasConcept C203014093 @default.
• W2625948944 hasConcept C2520015 @default.
• W2625948944 hasConcept C2776363554 @default.
• W2625948944 hasConcept C2776432469 @default.
• W2625948944 hasConcept C2777267240 @default.
• W2625948944 hasConcept C2777400515 @default.
• W2625948944 hasConcept C2779428903 @default.
• W2625948944 hasConcept C2780426850 @default.
• W2625948944 hasConcept C2780804394 @default.
• W2625948944 hasConcept C28328180 @default.
• W2625948944 hasConcept C55493867 @default.
• W2625948944 hasConcept C68434959 @default.
• W2625948944 hasConcept C69103154 @default.
• W2625948944 hasConcept C71924100 @default.
• W2625948944 hasConcept C86803240 @default.

• next