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- W2626042360 endingPage "1253" @default.
- W2626042360 startingPage "1245" @default.
- W2626042360 abstract "Cholangiocytes, like most cells, express primary cilia extending from their membranes. These organelles function as antennae which detect stimuli from bile and transmit the information into cells regulating several signaling pathways involved in secretion, proliferation and apoptosis. The ability of primary cilia to detect different signals is provided by ciliary associated proteins which are expressed in its membrane. Defects in the structure and/or function of these organelles lead to cholangiociliopathies that result in cholangiocyte hyperproliferation, altered fluid secretion and absorption. Since primary cilia dysfunction has been observed in several epithelial tumors, including cholangiocarcinoma (CCA), primary cilia have been proposed as tumor suppressor organelles. In addition, the loss of cilia is associated with dysregulation of several molecular pathways resulting in CCA development and progression. Thus, restoration of the primary cilia may be a potential therapeutic approach for several ciliopathies and CCA." @default.
- W2626042360 created "2017-06-23" @default.
- W2626042360 creator A5017002266 @default.
- W2626042360 creator A5032125798 @default.
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- W2626042360 creator A5050104830 @default.
- W2626042360 creator A5063586925 @default.
- W2626042360 creator A5065588347 @default.
- W2626042360 date "2018-04-01" @default.
- W2626042360 modified "2023-10-18" @default.
- W2626042360 title "The cholangiocyte primary cilium in health and disease" @default.
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