Matches in SemOpenAlex for { <https://semopenalex.org/work/W2626172993> ?p ?o ?g. }
- W2626172993 endingPage "1370" @default.
- W2626172993 startingPage "1354" @default.
- W2626172993 abstract "The brain’s white matter is highly vulnerable to reductions in cerebral blood flow via mechanisms that may involve elevated microgliosis and pro-inflammatory pathways. In the present study, the effects of severe cerebral hypoperfusion were investigated on white matter function and inflammation. Male C57Bl/6J mice underwent bilateral common carotid artery stenosis and white matter function was assessed at seven days with electrophysiology in response to evoked compound action potentials (CAPs) in the corpus callosum. The peak latency of CAPs and axonal refractoriness was increased following hypoperfusion, indicating a marked functional impairment in white matter, which was paralleled by axonal and myelin pathology and increased density and numbers of microglia/macrophages. The functional impairment in peak latency was significantly correlated with increased microglia/macrophages. Dimethyl fumarate (DMF; 100 mg/kg), a drug with anti-inflammatory properties, was found to reduce peak latency but not axonal refractoriness. DMF had no effect on hypoperfusion-induced axonal and myelin pathology. The density of microglia/macrophages was significantly increased in vehicle-treated hypoperfused mice, whereas DMF-treated hypoperfused mice had similar levels to that of sham-treated mice. The study suggests that increased microglia/macrophages following cerebral hypoperfusion contributes to the functional impairment in white matter that may be amenable to modulation by DMF." @default.
- W2626172993 created "2017-06-23" @default.
- W2626172993 creator A5006025723 @default.
- W2626172993 creator A5009980458 @default.
- W2626172993 creator A5011542402 @default.
- W2626172993 creator A5022950217 @default.
- W2626172993 creator A5050422179 @default.
- W2626172993 creator A5068239780 @default.
- W2626172993 creator A5074606033 @default.
- W2626172993 creator A5083175277 @default.
- W2626172993 creator A5085638268 @default.
- W2626172993 creator A5086627945 @default.
- W2626172993 date "2017-06-13" @default.
- W2626172993 modified "2023-10-18" @default.
- W2626172993 title "Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators" @default.
- W2626172993 cites W1157059961 @default.
- W2626172993 cites W1509253662 @default.
- W2626172993 cites W1572154272 @default.
- W2626172993 cites W1839080396 @default.
- W2626172993 cites W1904083131 @default.
- W2626172993 cites W1945436779 @default.
- W2626172993 cites W1966603452 @default.
- W2626172993 cites W1971355501 @default.
- W2626172993 cites W1973144368 @default.
- W2626172993 cites W1973465980 @default.
- W2626172993 cites W1975749842 @default.
- W2626172993 cites W1978094617 @default.
- W2626172993 cites W1978990157 @default.
- W2626172993 cites W1979741105 @default.
- W2626172993 cites W1980659881 @default.
- W2626172993 cites W1985633888 @default.
- W2626172993 cites W1986074216 @default.
- W2626172993 cites W1986421230 @default.
- W2626172993 cites W1991086765 @default.
- W2626172993 cites W1991530671 @default.
- W2626172993 cites W1993261308 @default.
- W2626172993 cites W1994314634 @default.
- W2626172993 cites W1995089232 @default.
- W2626172993 cites W1995175302 @default.
- W2626172993 cites W1999494818 @default.
- W2626172993 cites W2004349171 @default.
- W2626172993 cites W2004906982 @default.
- W2626172993 cites W2006858820 @default.
- W2626172993 cites W2008549510 @default.
- W2626172993 cites W2011854877 @default.
- W2626172993 cites W2015556961 @default.
- W2626172993 cites W2022905263 @default.
- W2626172993 cites W2023236768 @default.
- W2626172993 cites W2024189727 @default.
- W2626172993 cites W2025879351 @default.
- W2626172993 cites W2028314455 @default.
- W2626172993 cites W2031765208 @default.
- W2626172993 cites W2032172950 @default.
- W2626172993 cites W2044226727 @default.
- W2626172993 cites W2051755424 @default.
- W2626172993 cites W2055599834 @default.
- W2626172993 cites W2056027186 @default.
- W2626172993 cites W2061068109 @default.
- W2626172993 cites W2065147739 @default.
- W2626172993 cites W2074945021 @default.
- W2626172993 cites W2081580584 @default.
- W2626172993 cites W2086615759 @default.
- W2626172993 cites W2088359248 @default.
- W2626172993 cites W2089435027 @default.
- W2626172993 cites W2094219604 @default.
- W2626172993 cites W2095547757 @default.
- W2626172993 cites W2108854105 @default.
- W2626172993 cites W2110463517 @default.
- W2626172993 cites W2112026166 @default.
- W2626172993 cites W2118917448 @default.
- W2626172993 cites W2120683729 @default.
- W2626172993 cites W2122083429 @default.
- W2626172993 cites W2122237062 @default.
- W2626172993 cites W2123444403 @default.
- W2626172993 cites W2125325535 @default.
- W2626172993 cites W2126737571 @default.
- W2626172993 cites W2136239752 @default.
- W2626172993 cites W2156026557 @default.
- W2626172993 cites W2157020351 @default.
- W2626172993 cites W2159245100 @default.
- W2626172993 cites W2163039160 @default.
- W2626172993 cites W2164913239 @default.
- W2626172993 cites W2172266463 @default.
- W2626172993 cites W2181210303 @default.
- W2626172993 cites W2182354787 @default.
- W2626172993 cites W2187114150 @default.
- W2626172993 cites W2222916705 @default.
- W2626172993 cites W2257141517 @default.
- W2626172993 cites W2260723492 @default.
- W2626172993 cites W2268807381 @default.
- W2626172993 cites W2309675626 @default.
- W2626172993 cites W2334492359 @default.
- W2626172993 cites W2336345979 @default.
- W2626172993 cites W2336862132 @default.
- W2626172993 cites W2345236041 @default.
- W2626172993 cites W2346726910 @default.
- W2626172993 cites W2411727429 @default.
- W2626172993 cites W2412510818 @default.