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- W2626223669 abstract "The autoimmune/inflammatory disorder psoriasis is characterized by keratinocyte proliferation and immune cell infiltration of the skin. TCR+CD3+CD4-CD8- double negative (DN) T cells can derive from CD8+ T cells through the down-regulation of CD8. The inhibitory molecule programmed death (PD-)1 is expressed on activated T cells and plays a role in the maintenance of peripheral tolerance. A subset of DN T cells, characterized by the expression of PD-1, has recently been demonstrated to be self-reactive. We demonstrate that a majority of DN T cells exhibits effector memory phenotypes, express IFN-γ, and fail to proliferate. DN T cells from psoriasis patients are characterized by reduced DNA methylation of the IFNG gene and increased PD-1 expression. Furthermore, PD-1 positive DN T cells infiltrate the epidermis in psoriatic skin lesions. Our observations offer additional insight into the molecular pathophysiology of plaque psoriasis and show promise as potential disease biomarkers and/or therapeutic targets for future interventions." @default.
- W2626223669 created "2017-06-23" @default.
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- W2626223669 date "2017-08-01" @default.
- W2626223669 modified "2023-10-02" @default.
- W2626223669 title "TCR + CD3 + CD4 − CD8 − effector T cells in psoriasis" @default.
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- W2626223669 doi "https://doi.org/10.1016/j.clim.2017.06.002" @default.
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