Matches in SemOpenAlex for { <https://semopenalex.org/work/W2626239677> ?p ?o ?g. }
- W2626239677 abstract "Abstract LH-21 is a triazol derivative that has been described as a low-permeant neutral CB1 antagonist, though its pharmacology is still unclear. It has been associated with anti-obesity actions in obese rats. However, its role in preventing type 2 diabetes (T2D) onset have not been studied yet. Given CB1 receptors remain as potential pharmacological targets to fight against obesity and T2D, we wanted to explore the metabolic impact of this compound in an animal model of obesity and pre-diabetes as well as the lack of relevant actions in related central processes such as anxiety. C57BL/6J mice were rendered obese and pre-diabetic by feeding a high-fat diet for 15 weeks and then treated with LH-21 or vehicle for two weeks. Food intake, body weight and glucose handling were assessed, together with other relevant parameters. Behavioural performance was evaluated by the open field test and the elevated plus maze. LH-21 did not affect food intake nor body weight but it improved glucose handling, displaying tissue-specific beneficial actions. Unexpectedly, LH-21 induced anxiolysis and reverted obesity-induced anxiety, apparently through GPR55 receptor. These results suggest that LH-21 can be a new candidate to fight against diabetes onset. Indeed, this compound shows potential in counteracting obesity-related anxiety." @default.
- W2626239677 created "2017-06-23" @default.
- W2626239677 creator A5004989757 @default.
- W2626239677 creator A5006497343 @default.
- W2626239677 creator A5011380766 @default.
- W2626239677 creator A5035131136 @default.
- W2626239677 creator A5037297701 @default.
- W2626239677 creator A5054652451 @default.
- W2626239677 creator A5061677162 @default.
- W2626239677 creator A5063603806 @default.
- W2626239677 creator A5073061508 @default.
- W2626239677 creator A5074801875 @default.
- W2626239677 creator A5080016822 @default.
- W2626239677 date "2017-06-21" @default.
- W2626239677 modified "2023-10-18" @default.
- W2626239677 title "The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice" @default.
- W2626239677 cites W11753821 @default.
- W2626239677 cites W1520490569 @default.
- W2626239677 cites W1853244388 @default.
- W2626239677 cites W1945015515 @default.
- W2626239677 cites W1977183929 @default.
- W2626239677 cites W1978543947 @default.
- W2626239677 cites W1984089454 @default.
- W2626239677 cites W1985395422 @default.
- W2626239677 cites W2004415631 @default.
- W2626239677 cites W2009659223 @default.
- W2626239677 cites W2022264320 @default.
- W2626239677 cites W2023235628 @default.
- W2626239677 cites W2029003083 @default.
- W2626239677 cites W2038667563 @default.
- W2626239677 cites W2052172874 @default.
- W2626239677 cites W2064503879 @default.
- W2626239677 cites W2064880478 @default.
- W2626239677 cites W2079860184 @default.
- W2626239677 cites W2085570274 @default.
- W2626239677 cites W2087444912 @default.
- W2626239677 cites W2090548255 @default.
- W2626239677 cites W2094409327 @default.
- W2626239677 cites W2104497132 @default.
- W2626239677 cites W2104652079 @default.
- W2626239677 cites W2107493582 @default.
- W2626239677 cites W2115824704 @default.
- W2626239677 cites W2117507851 @default.
- W2626239677 cites W2126283585 @default.
- W2626239677 cites W2128514367 @default.
- W2626239677 cites W2130784808 @default.
- W2626239677 cites W2143150187 @default.
- W2626239677 cites W2162112945 @default.
- W2626239677 cites W2169342042 @default.
- W2626239677 cites W2270230636 @default.
- W2626239677 cites W2501047946 @default.
- W2626239677 cites W2514954209 @default.
- W2626239677 cites W2521516923 @default.
- W2626239677 cites W2951790200 @default.
- W2626239677 doi "https://doi.org/10.1038/s41598-017-03292-w" @default.
- W2626239677 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5479807" @default.
- W2626239677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28638091" @default.
- W2626239677 hasPublicationYear "2017" @default.
- W2626239677 type Work @default.
- W2626239677 sameAs 2626239677 @default.
- W2626239677 citedByCount "21" @default.
- W2626239677 countsByYear W26262396772018 @default.
- W2626239677 countsByYear W26262396772019 @default.
- W2626239677 countsByYear W26262396772020 @default.
- W2626239677 countsByYear W26262396772021 @default.
- W2626239677 countsByYear W26262396772022 @default.
- W2626239677 countsByYear W26262396772023 @default.
- W2626239677 crossrefType "journal-article" @default.
- W2626239677 hasAuthorship W2626239677A5004989757 @default.
- W2626239677 hasAuthorship W2626239677A5006497343 @default.
- W2626239677 hasAuthorship W2626239677A5011380766 @default.
- W2626239677 hasAuthorship W2626239677A5035131136 @default.
- W2626239677 hasAuthorship W2626239677A5037297701 @default.
- W2626239677 hasAuthorship W2626239677A5054652451 @default.
- W2626239677 hasAuthorship W2626239677A5061677162 @default.
- W2626239677 hasAuthorship W2626239677A5063603806 @default.
- W2626239677 hasAuthorship W2626239677A5073061508 @default.
- W2626239677 hasAuthorship W2626239677A5074801875 @default.
- W2626239677 hasAuthorship W2626239677A5080016822 @default.
- W2626239677 hasBestOaLocation W26262396771 @default.
- W2626239677 hasConcept C118552586 @default.
- W2626239677 hasConcept C126322002 @default.
- W2626239677 hasConcept C134018914 @default.
- W2626239677 hasConcept C148001335 @default.
- W2626239677 hasConcept C170493617 @default.
- W2626239677 hasConcept C173586616 @default.
- W2626239677 hasConcept C2776885963 @default.
- W2626239677 hasConcept C2777180221 @default.
- W2626239677 hasConcept C2779085643 @default.
- W2626239677 hasConcept C46721173 @default.
- W2626239677 hasConcept C511355011 @default.
- W2626239677 hasConcept C544821477 @default.
- W2626239677 hasConcept C555293320 @default.
- W2626239677 hasConcept C558461103 @default.
- W2626239677 hasConcept C71924100 @default.
- W2626239677 hasConcept C98274493 @default.
- W2626239677 hasConceptScore W2626239677C118552586 @default.
- W2626239677 hasConceptScore W2626239677C126322002 @default.
- W2626239677 hasConceptScore W2626239677C134018914 @default.
- W2626239677 hasConceptScore W2626239677C148001335 @default.