FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2626395940> ?p ?o ?g. }

• W2626395940 endingPage "927" @default.
• W2626395940 startingPage "927" @default.
• W2626395940 abstract "<ns4:p>The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view. In noise-induced hearing loss, exposures causing only reversible threshold shifts (and no hair cell loss) nevertheless cause permanent loss of >50% of the synaptic connections between hair cells and the auditory nerve. Similarly, in age-related hearing loss, degeneration of cochlear synapses precedes both hair cell loss and threshold elevation. This primary neural degeneration has remained a “hidden hearing loss” for two reasons: 1) the neuronal cell bodies survive for years despite loss of synaptic connection with hair cells, and 2) the degeneration is selective for auditory nerve fibers with high thresholds. Although not required for threshold detection when quiet, these high-threshold fibers are critical for hearing in noisy environments. Research suggests that primary neural degeneration is an important contributor to the perceptual handicap in sensorineural hearing loss, and it may be key to the generation of tinnitus and other associated perceptual anomalies. In cases where the hair cells survive, neurotrophin therapies can elicit neurite outgrowth from surviving auditory neurons and re-establishment of their peripheral synapses; thus, treatments may be on the horizon.</ns4:p>" @default.
• W2626395940 created "2017-06-23" @default.
• W2626395940 creator A5051315497 @default.
• W2626395940 date "2017-06-16" @default.
• W2626395940 modified "2023-10-14" @default.
• W2626395940 title "Noise-induced and age-related hearing loss: new perspectives and potential therapies" @default.
• W2626395940 cites W1276986011 @default.
• W2626395940 cites W1497444511 @default.
• W2626395940 cites W1582872727 @default.
• W2626395940 cites W1975616153 @default.
• W2626395940 cites W1977448672 @default.
• W2626395940 cites W1977877161 @default.
• W2626395940 cites W1981075126 @default.
• W2626395940 cites W1987022414 @default.
• W2626395940 cites W1987343613 @default.
• W2626395940 cites W1988508433 @default.
• W2626395940 cites W1990613154 @default.
• W2626395940 cites W2004543480 @default.
• W2626395940 cites W2004847756 @default.
• W2626395940 cites W2009133456 @default.
• W2626395940 cites W2009984517 @default.
• W2626395940 cites W2012649986 @default.
• W2626395940 cites W2018833577 @default.
• W2626395940 cites W2021172692 @default.
• W2626395940 cites W2021229079 @default.
• W2626395940 cites W2021987058 @default.
• W2626395940 cites W2023575573 @default.
• W2626395940 cites W2025174752 @default.
• W2626395940 cites W2031001883 @default.
• W2626395940 cites W2033046255 @default.
• W2626395940 cites W2034992309 @default.
• W2626395940 cites W2036100925 @default.
• W2626395940 cites W2045032466 @default.
• W2626395940 cites W2047894292 @default.
• W2626395940 cites W2050140588 @default.
• W2626395940 cites W2056829537 @default.
• W2626395940 cites W2056983834 @default.
• W2626395940 cites W2057823029 @default.
• W2626395940 cites W2059974905 @default.
• W2626395940 cites W2061759133 @default.
• W2626395940 cites W2063464173 @default.
• W2626395940 cites W2066538536 @default.
• W2626395940 cites W2073811072 @default.
• W2626395940 cites W2074378742 @default.
• W2626395940 cites W2080203024 @default.
• W2626395940 cites W2089138302 @default.
• W2626395940 cites W2097498366 @default.
• W2626395940 cites W2102377881 @default.
• W2626395940 cites W2112673780 @default.
• W2626395940 cites W2112722770 @default.
• W2626395940 cites W2114226942 @default.
• W2626395940 cites W2123007261 @default.
• W2626395940 cites W2137106144 @default.
• W2626395940 cites W2140689828 @default.
• W2626395940 cites W2152933007 @default.
• W2626395940 cites W2157316037 @default.
• W2626395940 cites W2161803347 @default.
• W2626395940 cites W2161851299 @default.
• W2626395940 cites W2166380239 @default.
• W2626395940 cites W2171993659 @default.
• W2626395940 cites W2185003217 @default.
• W2626395940 cites W2203895492 @default.
• W2626395940 cites W222028059 @default.
• W2626395940 cites W2268695670 @default.
• W2626395940 cites W2314835883 @default.
• W2626395940 cites W2320204433 @default.
• W2626395940 cites W2320927083 @default.
• W2626395940 cites W2333396177 @default.
• W2626395940 cites W2345177852 @default.
• W2626395940 cites W2405497525 @default.
• W2626395940 cites W2406479903 @default.
• W2626395940 cites W2413383837 @default.
• W2626395940 cites W2482089764 @default.
• W2626395940 cites W2514144657 @default.
• W2626395940 cites W2520285939 @default.
• W2626395940 cites W2520380456 @default.
• W2626395940 cites W2546970346 @default.
• W2626395940 cites W2548222597 @default.
• W2626395940 cites W2550917727 @default.
• W2626395940 cites W2568449460 @default.
• W2626395940 cites W4249513861 @default.
• W2626395940 cites W4253934441 @default.
• W2626395940 doi "https://doi.org/10.12688/f1000research.11310.1" @default.
• W2626395940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5482333" @default.
• W2626395940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28690836" @default.
• W2626395940 hasPublicationYear "2017" @default.
• W2626395940 type Work @default.
• W2626395940 sameAs 2626395940 @default.
• W2626395940 citedByCount "182" @default.
• W2626395940 countsByYear W26263959402017 @default.
• W2626395940 countsByYear W26263959402018 @default.
• W2626395940 countsByYear W26263959402019 @default.
• W2626395940 countsByYear W26263959402020 @default.
• W2626395940 countsByYear W26263959402021 @default.
• W2626395940 countsByYear W26263959402022 @default.
• W2626395940 countsByYear W26263959402023 @default.
• W2626395940 crossrefType "journal-article" @default.
• W2626395940 hasAuthorship W2626395940A5051315497 @default.

• next