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• W2626408918 endingPage "e0179096" @default.
• W2626408918 startingPage "e0179096" @default.
• W2626408918 abstract "Background and aims Interferon (IFN)- free direct antiviral agents (DAAs) with rapid HCV eradication might evoke immunological reconstitutions, and some early recurrences of HCC after IFN-free DAAs have been reported. This study aimed to investigate whether natural killer group 2, member D (NKG2D) predicts early emergence of HCC after IFN-free DAAs. Methods We conducted a clinical practice-based observational study of 101 patients infected with genotype 1 HCV who received IFN-free (DAAs), and stratified them into those who did or did not develop early (i.e., during the 6-month surveillance period following treatment.) recurrence or occurrence of clinically evident HCC. We also analyzed the peripheral blood mononuclear cells, both before treatment and at end of treatment (EOT), of 24 of the patients who received IFN-free DAAs, and 16 who received IFN-combined protease inhibitor. Results We found early emergence of clinically evident HCC after IFN-free DAAs in 12 (12%) patients. Higher pre-treatment NKG2D expression, higher FIB-4 score, previous HCC history and failure to achieve sustained viral response were significant factors correlating to early HCC emergence. After IFN-free DAAs, a rapid decrease of NKG2D at EOT correlated with early HCC emergence in the IFN-free DAA-treated patients, but not in patients treated with the IFN-combined regimen. The decrease of NKG2D until EOT was predictive of early HCC emergence at a cut-off of -52% (AUC = 0.92). Conclusions On-treatment decrease of NKG2D may be a useful predictor of early emerging HCC in patients treated with IFN-free DAAs." @default.
• W2626408918 created "2017-06-23" @default.
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• W2626408918 date "2017-06-15" @default.
• W2626408918 modified "2023-09-25" @default.
• W2626408918 title "On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C" @default.
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• W2626408918 doi "https://doi.org/10.1371/journal.pone.0179096" @default.
• W2626408918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5472371" @default.
• W2626408918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28617830" @default.
• W2626408918 hasPublicationYear "2017" @default.
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