FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2626465128> ?p ?o ?g. }

• W2626465128 endingPage "663" @default.
• W2626465128 startingPage "653" @default.
• W2626465128 abstract "Protein phosphorylation, mediated by protein kinases, is a key event in the regulation of eukaryotic signal transduction. The majority of eukaryotic protein kinases perform phosphoryl transfer, assisted by two divalent metal ions. About 10% of all human protein kinases are, however, thought to be catalytically inactive. These kinases lack conserved residues of the kinase core and are classified as pseudokinases. Yet, it has been demonstrated that pseudokinases are critically involved in biological functions. Here, we show how pseudokinases have developed strategies by modifying amino acid residues in order to achieve stable, active-like conformations. This includes binding of the co-substrate ATP in a two metal-, one metal- or even no metal-binding mode. Examples of the respective pseudokinases are provided on a structural basis and compared with a canonical protein kinase, Protein Kinase A. Moreover, the functional roles of both independent metal-binding sites, Me1 and Me2, are discussed. Lack of phosphotransferase activity does not implicate a loss of function and can easily point to alternative roles of pseudokinases, i.e. acting as switches or scaffolds, and having evolved as components crucial for cellular cross-talk and signaling. Interestingly, pseudokinases are present in all kingdoms of life and their specific roles remain enigmatic. More studies are needed to unravel the crucial functions of those interesting proteins." @default.
• W2626465128 created "2017-06-23" @default.
• W2626465128 creator A5006568947 @default.
• W2626465128 creator A5081112969 @default.
• W2626465128 date "2017-06-15" @default.
• W2626465128 modified "2023-10-11" @default.
• W2626465128 title "Metal coordination in kinases and pseudokinases" @default.
• W2626465128 cites W1501199419 @default.
• W2626465128 cites W1538925875 @default.
• W2626465128 cites W1954353020 @default.
• W2626465128 cites W1969119726 @default.
• W2626465128 cites W1971032467 @default.
• W2626465128 cites W1973437349 @default.
• W2626465128 cites W1976096319 @default.
• W2626465128 cites W1976760923 @default.
• W2626465128 cites W1992325160 @default.
• W2626465128 cites W1994794059 @default.
• W2626465128 cites W2000390423 @default.
• W2626465128 cites W2015956088 @default.
• W2626465128 cites W2019846233 @default.
• W2626465128 cites W2019903301 @default.
• W2626465128 cites W2020257412 @default.
• W2626465128 cites W2024873935 @default.
• W2626465128 cites W2026861452 @default.
• W2626465128 cites W2030205108 @default.
• W2626465128 cites W2033630329 @default.
• W2626465128 cites W2036915355 @default.
• W2626465128 cites W2040077679 @default.
• W2626465128 cites W2043224156 @default.
• W2626465128 cites W2050103345 @default.
• W2626465128 cites W2056924558 @default.
• W2626465128 cites W2061078665 @default.
• W2626465128 cites W2067405360 @default.
• W2626465128 cites W2071356747 @default.
• W2626465128 cites W2076882737 @default.
• W2626465128 cites W2078277064 @default.
• W2626465128 cites W2079156404 @default.
• W2626465128 cites W2079781020 @default.
• W2626465128 cites W2085709611 @default.
• W2626465128 cites W2086221920 @default.
• W2626465128 cites W2090342453 @default.
• W2626465128 cites W2094014906 @default.
• W2626465128 cites W2098698214 @default.
• W2626465128 cites W2099387330 @default.
• W2626465128 cites W2099963467 @default.
• W2626465128 cites W2120408260 @default.
• W2626465128 cites W2125074129 @default.
• W2626465128 cites W2127192155 @default.
• W2626465128 cites W2139362357 @default.
• W2626465128 cites W2140002349 @default.
• W2626465128 cites W2141524439 @default.
• W2626465128 cites W2151542719 @default.
• W2626465128 cites W2155009402 @default.
• W2626465128 cites W2155445915 @default.
• W2626465128 cites W2156682932 @default.
• W2626465128 cites W2158850252 @default.
• W2626465128 cites W2160761064 @default.
• W2626465128 cites W2166542272 @default.
• W2626465128 cites W2168822202 @default.
• W2626465128 cites W2325211585 @default.
• W2626465128 cites W2389126460 @default.
• W2626465128 cites W2409039558 @default.
• W2626465128 cites W2423812888 @default.
• W2626465128 cites W2550847151 @default.
• W2626465128 cites W4236567810 @default.
• W2626465128 cites W965786257 @default.
• W2626465128 doi "https://doi.org/10.1042/bst20160327" @default.
• W2626465128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28620027" @default.
• W2626465128 hasPublicationYear "2017" @default.
• W2626465128 type Work @default.
• W2626465128 sameAs 2626465128 @default.
• W2626465128 citedByCount "11" @default.
• W2626465128 countsByYear W26264651282017 @default.
• W2626465128 countsByYear W26264651282018 @default.
• W2626465128 countsByYear W26264651282019 @default.
• W2626465128 countsByYear W26264651282020 @default.
• W2626465128 countsByYear W26264651282021 @default.
• W2626465128 countsByYear W26264651282022 @default.
• W2626465128 crossrefType "journal-article" @default.
• W2626465128 hasAuthorship W2626465128A5006568947 @default.
• W2626465128 hasAuthorship W2626465128A5081112969 @default.
• W2626465128 hasBestOaLocation W26264651281 @default.
• W2626465128 hasConcept C11960822 @default.
• W2626465128 hasConcept C184235292 @default.
• W2626465128 hasConcept C185592680 @default.
• W2626465128 hasConcept C55493867 @default.
• W2626465128 hasConcept C62478195 @default.
• W2626465128 hasConcept C86803240 @default.
• W2626465128 hasConcept C95444343 @default.
• W2626465128 hasConcept C97029542 @default.
• W2626465128 hasConceptScore W2626465128C11960822 @default.
• W2626465128 hasConceptScore W2626465128C184235292 @default.
• W2626465128 hasConceptScore W2626465128C185592680 @default.
• W2626465128 hasConceptScore W2626465128C55493867 @default.
• W2626465128 hasConceptScore W2626465128C62478195 @default.
• W2626465128 hasConceptScore W2626465128C86803240 @default.
• W2626465128 hasConceptScore W2626465128C95444343 @default.
• W2626465128 hasConceptScore W2626465128C97029542 @default.

• next