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• W2626486535 abstract "Abstract Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. We aimed to identify atypical FC between the periaqueductal gray (PAG) and other brain areas in rats induced by repeated meningeal nociception. The rat model was established by infusing an inflammatory soup (IS) through supradural catheters in conscious rats. Quiescent and face-grooming behaviors were observed to assess nociceptive behavior. FC analysis seeded on the PAG was performed on rats 21 days after IS infusion. The rats exhibited nociceptive behavior correlates of human behaviors associated with migraine after IS infusion. The PAG showed increased FC with the prefrontal cortex, cingulate gyrus, and motor cortex but decreased FC with the basal ganglia, dorsal lateral thalamus, internal capsule and prelimbic cortex in the rat model. The atypical FC of the PAG with brain regions in the rat model that are involved in nociception, somatosensory processing, emotional processing, and pain modulation are consistent with the clinical data from migraineurs, indicate that resting-state FC changes in migraine patients may be a consequence of headache attacks, and further validate this rat model of chronic migraine." @default.
• W2626486535 created "2017-06-23" @default.
• W2626486535 creator A5022281821 @default.
• W2626486535 creator A5053582982 @default.
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• W2626486535 date "2017-06-21" @default.
• W2626486535 modified "2023-10-15" @default.
• W2626486535 title "Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache" @default.
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• W2626486535 doi "https://doi.org/10.1038/s41598-017-04060-6" @default.
• W2626486535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5479837" @default.
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• W2626486535 hasPublicationYear "2017" @default.
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