Matches in SemOpenAlex for { <https://semopenalex.org/work/W2626499425> ?p ?o ?g. }
- W2626499425 endingPage "1711" @default.
- W2626499425 startingPage "1692" @default.
- W2626499425 abstract "The benefits and detriments of recombination for adaptive evolution have been studied both theoretically and experimentally, with conflicting predictions and observations. Most pertinent experiments examine recombination's effects in an unchanging environment and do not study its genomewide effects. Here, we evolved six replicate populations of either highly recombining R+ or lowly recombining R- E. coli strains in a changing environment, by introducing the novel nutrients L-arabinose or indole into the environment. The experiment's ancestral strains are not viable on these nutrients, but 130 generations of adaptive evolution were sufficient to render them viable. Recombination conferred a more pronounced advantage to populations adapting to indole. To study the genomic changes associated with this advantage, we sequenced the genomes of 384 clones isolated from selected replicates at the end of the experiment. These genomes harbour complex changes that range from point mutations to large-scale DNA amplifications. Among several candidate adaptive mutations, those in the tryptophanase regulator tnaC stand out, because the tna operon in which it resides has a known role in indole metabolism. One of the highly recombining populations also shows a significant excess of large-scale segmental DNA amplifications that include the tna operon. This lineage also shows a unique and potentially adaptive combination of point mutations and DNA amplifications that may have originated independently from one another, to be joined later by recombination. Our data illustrate that the advantages of recombination for adaptive evolution strongly depend on the environment and that they can be associated with complex genomic changes." @default.
- W2626499425 created "2017-06-23" @default.
- W2626499425 creator A5017478382 @default.
- W2626499425 creator A5052376956 @default.
- W2626499425 creator A5079730045 @default.
- W2626499425 date "2017-07-13" @default.
- W2626499425 modified "2023-10-01" @default.
- W2626499425 title "The role of recombination in evolutionary adaptation of<i>Escherichia coli</i>to a novel nutrient" @default.
- W2626499425 cites W111180464 @default.
- W2626499425 cites W147290053 @default.
- W2626499425 cites W1490719520 @default.
- W2626499425 cites W1502125372 @default.
- W2626499425 cites W1511452332 @default.
- W2626499425 cites W1540428236 @default.
- W2626499425 cites W1561849362 @default.
- W2626499425 cites W1586374390 @default.
- W2626499425 cites W1597874994 @default.
- W2626499425 cites W1817014772 @default.
- W2626499425 cites W1919257374 @default.
- W2626499425 cites W1925508000 @default.
- W2626499425 cites W1968524431 @default.
- W2626499425 cites W1982724189 @default.
- W2626499425 cites W1989695882 @default.
- W2626499425 cites W1992012524 @default.
- W2626499425 cites W1995875735 @default.
- W2626499425 cites W1997541288 @default.
- W2626499425 cites W2001369581 @default.
- W2626499425 cites W2003485756 @default.
- W2626499425 cites W2004778468 @default.
- W2626499425 cites W2005947049 @default.
- W2626499425 cites W2006492816 @default.
- W2626499425 cites W2006790542 @default.
- W2626499425 cites W2007325090 @default.
- W2626499425 cites W2012980277 @default.
- W2626499425 cites W2013647724 @default.
- W2626499425 cites W2014496483 @default.
- W2626499425 cites W2019743611 @default.
- W2626499425 cites W2022733429 @default.
- W2626499425 cites W2023925845 @default.
- W2626499425 cites W2034979835 @default.
- W2626499425 cites W2037830418 @default.
- W2626499425 cites W2040041807 @default.
- W2626499425 cites W2041949408 @default.
- W2626499425 cites W2043272858 @default.
- W2626499425 cites W2045716211 @default.
- W2626499425 cites W2056613057 @default.
- W2626499425 cites W2056859258 @default.
- W2626499425 cites W2067713285 @default.
- W2626499425 cites W2070971101 @default.
- W2626499425 cites W2079024062 @default.
- W2626499425 cites W2080647790 @default.
- W2626499425 cites W2085575847 @default.
- W2626499425 cites W2088261612 @default.
- W2626499425 cites W2106578986 @default.
- W2626499425 cites W2106905351 @default.
- W2626499425 cites W2106975426 @default.
- W2626499425 cites W2109947766 @default.
- W2626499425 cites W2111012231 @default.
- W2626499425 cites W2112145740 @default.
- W2626499425 cites W2112642778 @default.
- W2626499425 cites W2115590956 @default.
- W2626499425 cites W2118168447 @default.
- W2626499425 cites W2119180969 @default.
- W2626499425 cites W2122700446 @default.
- W2626499425 cites W2123856603 @default.
- W2626499425 cites W2125447804 @default.
- W2626499425 cites W2125685565 @default.
- W2626499425 cites W2126183065 @default.
- W2626499425 cites W2128884353 @default.
- W2626499425 cites W2130315111 @default.
- W2626499425 cites W2131271579 @default.
- W2626499425 cites W2133991766 @default.
- W2626499425 cites W2134000614 @default.
- W2626499425 cites W2135409136 @default.
- W2626499425 cites W2137779717 @default.
- W2626499425 cites W2138952930 @default.
- W2626499425 cites W2142402047 @default.
- W2626499425 cites W2142812124 @default.
- W2626499425 cites W2145646295 @default.
- W2626499425 cites W2146217823 @default.
- W2626499425 cites W2147415326 @default.
- W2626499425 cites W2148559943 @default.
- W2626499425 cites W2150012832 @default.
- W2626499425 cites W2157672734 @default.
- W2626499425 cites W2158423461 @default.
- W2626499425 cites W2158714788 @default.
- W2626499425 cites W2160530156 @default.
- W2626499425 cites W2161227486 @default.
- W2626499425 cites W2161425107 @default.
- W2626499425 cites W2163240067 @default.
- W2626499425 cites W2164832298 @default.
- W2626499425 cites W2166468415 @default.
- W2626499425 cites W2167708455 @default.
- W2626499425 cites W2170551349 @default.
- W2626499425 cites W2214414678 @default.
- W2626499425 cites W2285484490 @default.
- W2626499425 cites W2289628470 @default.
- W2626499425 cites W2290768068 @default.