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- W2626553654 abstract "A new sample-delivery method for serial X-ray crystallography exploits the full repetition rate of the X-ray free-electron laser at the LCLS facility, thus enabling efficient, high-speed data collection to solve the three-dimensional structures of viruses. We report a method for serial X-ray crystallography at X-ray free-electron lasers (XFELs), which allows for full use of the current 120-Hz repetition rate of the Linear Coherent Light Source (LCLS). Using a micropatterned silicon chip in combination with the high-speed Roadrunner goniometer for sample delivery, we were able to determine the crystal structures of the picornavirus bovine enterovirus 2 (BEV2) and the cytoplasmic polyhedrosis virus type 18 polyhedrin, with total data collection times of less than 14 and 10 min, respectively. Our method requires only micrograms of sample and should therefore broaden the applicability of serial femtosecond crystallography to challenging projects for which only limited sample amounts are available. By synchronizing the sample exchange to the XFEL repetition rate, our method allows for most efficient use of the limited beam time available at XFELs and should enable a substantial increase in sample throughput at these facilities." @default.
- W2626553654 created "2017-06-23" @default.
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- W2626553654 date "2017-06-19" @default.
- W2626553654 modified "2023-10-15" @default.
- W2626553654 title "High-speed fixed-target serial virus crystallography" @default.
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- W2626553654 doi "https://doi.org/10.1038/nmeth.4335" @default.
- W2626553654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5588887" @default.
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- W2626553654 hasPublicationYear "2017" @default.
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