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• W2626577148 abstract "Chronic pain states are highly prevalent and yet poorly controlled by currently available analgesics, representing an enormous clinical, societal, and economic burden. Existing pain medications have significant limitations and adverse effects including tolerance, dependence, gastrointestinal dysfunction, cognitive impairment, and a narrow therapeutic window, making the search for novel analgesics ever more important. In this article, we review the role of an important endogenous pain control system, the endocannabinoid (EC) system, in the sensory, emotional, and cognitive aspects of pain. Herein, we briefly cover the discovery of the EC system and its role in pain processing pathways, before concentrating on three areas of current major interest in EC pain research; 1. Pharmacological enhancement of endocannabinoid activity (via blockade of EC metabolism or allosteric modulation of CB1receptors); 2. The EC System and stress-induced modulation of pain; and 3. The EC system & medial prefrontal cortex (mPFC) dysfunction in pain states. Whilst we focus predominantly on the preclinical data, we also include extensive discussion of recent clinical failures of endocannabinoid-related therapies, the future potential of these approaches, and important directions for future research on the EC system and pain. This article is part of the Special Issue entitled A New Dawn in Cannabinoid Neurobiology." @default.
• W2626577148 created "2017-06-23" @default.
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• W2626577148 date "2017-09-01" @default.
• W2626577148 modified "2023-10-10" @default.
• W2626577148 title "The cannabinoid system and pain" @default.
• W2626577148 cites W112333178 @default.
• W2626577148 cites W1480176511 @default.
• W2626577148 cites W1489737221 @default.
• W2626577148 cites W1492563575 @default.
• W2626577148 cites W1500005891 @default.
• W2626577148 cites W1500759439 @default.
• W2626577148 cites W1506141559 @default.
• W2626577148 cites W1521347253 @default.
• W2626577148 cites W1522286943 @default.
• W2626577148 cites W1539660754 @default.
• W2626577148 cites W1549092682 @default.
• W2626577148 cites W1560013893 @default.
• W2626577148 cites W1575019839 @default.
• W2626577148 cites W1591647183 @default.
• W2626577148 cites W1594710133 @default.
• W2626577148 cites W1683401737 @default.
• W2626577148 cites W1832918544 @default.
• W2626577148 cites W1836729582 @default.
• W2626577148 cites W1876729781 @default.
• W2626577148 cites W1892287994 @default.
• W2626577148 cites W1902140575 @default.
• W2626577148 cites W1907919347 @default.
• W2626577148 cites W1909544721 @default.
• W2626577148 cites W1924044899 @default.
• W2626577148 cites W1943422062 @default.
• W2626577148 cites W1962384335 @default.
• W2626577148 cites W1964178864 @default.
• W2626577148 cites W1965511761 @default.
• W2626577148 cites W1965539337 @default.
• W2626577148 cites W1966648294 @default.
• W2626577148 cites W1969254522 @default.
• W2626577148 cites W1969338731 @default.
• W2626577148 cites W1970307887 @default.
• W2626577148 cites W1971339908 @default.
• W2626577148 cites W1973847365 @default.
• W2626577148 cites W1974054828 @default.
• W2626577148 cites W1976037358 @default.
• W2626577148 cites W1976727172 @default.
• W2626577148 cites W1977502547 @default.
• W2626577148 cites W1979046480 @default.
• W2626577148 cites W1979495995 @default.
• W2626577148 cites W1980028866 @default.
• W2626577148 cites W1982291289 @default.
• W2626577148 cites W1982429227 @default.
• W2626577148 cites W1984624900 @default.
• W2626577148 cites W1985688040 @default.
• W2626577148 cites W1986003147 @default.
• W2626577148 cites W1986404316 @default.
• W2626577148 cites W1987392559 @default.
• W2626577148 cites W1987729666 @default.
• W2626577148 cites W1988353820 @default.
• W2626577148 cites W1988795372 @default.
• W2626577148 cites W1989073099 @default.
• W2626577148 cites W1989155012 @default.
• W2626577148 cites W1989363579 @default.
• W2626577148 cites W1990912842 @default.
• W2626577148 cites W1991319303 @default.
• W2626577148 cites W1991497324 @default.
• W2626577148 cites W1994207575 @default.
• W2626577148 cites W1995048478 @default.
• W2626577148 cites W1995458911 @default.
• W2626577148 cites W1996295130 @default.
• W2626577148 cites W1996348712 @default.
• W2626577148 cites W1997833489 @default.
• W2626577148 cites W2001196318 @default.
• W2626577148 cites W2001562560 @default.
• W2626577148 cites W2002355116 @default.
• W2626577148 cites W2003039924 @default.
• W2626577148 cites W2005449195 @default.
• W2626577148 cites W2007034094 @default.
• W2626577148 cites W2007373797 @default.
• W2626577148 cites W2008749179 @default.
• W2626577148 cites W2009864778 @default.
• W2626577148 cites W2011223687 @default.
• W2626577148 cites W2011868334 @default.
• W2626577148 cites W2013792428 @default.
• W2626577148 cites W2014359029 @default.
• W2626577148 cites W2017221863 @default.
• W2626577148 cites W2018479387 @default.
• W2626577148 cites W2018876606 @default.
• W2626577148 cites W2019144812 @default.
• W2626577148 cites W2019162216 @default.
• W2626577148 cites W2020073898 @default.
• W2626577148 cites W2020299098 @default.
• W2626577148 cites W2021462702 @default.
• W2626577148 cites W2022332600 @default.
• W2626577148 cites W2022676940 @default.
• W2626577148 cites W2023048273 @default.

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