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- W2626606311 abstract "ABSTRACT eIF4A is a DEAD-box RNA-dependent ATPase thought to unwind RNA secondary structure in the 5′-untranslated regions (UTRs) of mRNAs to promote their recruitment to the eukaryotic translation pre-initiation complex (PIC). We show that eIF4A’s ATPase activity is markedly stimulated in the presence of the PIC, independently of eIF4E•eIF4G, but dependent on subunits i and g of the heteromeric eIF3 complex. Surprisingly, eIF4A accelerated the rate of recruitment of all mRNAs tested, regardless of their degree of structural complexity. Structures in the 5′-UTR and 3′ of the start codon synergistically inhibit mRNA recruitment in a manner relieved by eIF4A, indicating that the factor does not act solely to melt hairpins in 5′-UTRs. Our findings that eIF4A functionally interacts with the PIC and plays important roles beyond unwinding 5’-UTR structure is consistent with a recent proposal that eIF4A modulates the conformation of the 40S ribosomal subunit to promote mRNA recruitment." @default.
- W2626606311 created "2017-06-23" @default.
- W2626606311 creator A5014224745 @default.
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- W2626606311 creator A5059939534 @default.
- W2626606311 creator A5067650722 @default.
- W2626606311 creator A5091088864 @default.
- W2626606311 date "2017-06-13" @default.
- W2626606311 modified "2023-10-16" @default.
- W2626606311 title "eIF4A is stimulated by the pre-initiation complex and enhances recruitment of mRNAs regardless of structural complexity" @default.
- W2626606311 cites W129375353 @default.
- W2626606311 cites W1454765678 @default.
- W2626606311 cites W1481065513 @default.
- W2626606311 cites W1493552793 @default.
- W2626606311 cites W1493978240 @default.
- W2626606311 cites W1557881499 @default.
- W2626606311 cites W1559327258 @default.
- W2626606311 cites W1922815468 @default.
- W2626606311 cites W1964099889 @default.
- W2626606311 cites W1968316142 @default.
- W2626606311 cites W1968895736 @default.
- W2626606311 cites W1973556963 @default.
- W2626606311 cites W1974640862 @default.
- W2626606311 cites W1978870437 @default.
- W2626606311 cites W1982525774 @default.
- W2626606311 cites W1985621907 @default.
- W2626606311 cites W1987625491 @default.
- W2626606311 cites W1991153932 @default.
- W2626606311 cites W1992359726 @default.
- W2626606311 cites W1996690481 @default.
- W2626606311 cites W2002961201 @default.
- W2626606311 cites W2003993220 @default.
- W2626606311 cites W2011503994 @default.
- W2626606311 cites W2012768611 @default.
- W2626606311 cites W2017789880 @default.
- W2626606311 cites W2019337061 @default.
- W2626606311 cites W2020458511 @default.
- W2626606311 cites W2021978074 @default.
- W2626606311 cites W2022141676 @default.
- W2626606311 cites W2024080095 @default.
- W2626606311 cites W2027917427 @default.
- W2626606311 cites W2035595761 @default.
- W2626606311 cites W2037576800 @default.
- W2626606311 cites W2038846224 @default.
- W2626606311 cites W2039885485 @default.
- W2626606311 cites W2040096973 @default.
- W2626606311 cites W2047405192 @default.
- W2626606311 cites W2047459430 @default.
- W2626606311 cites W2054884192 @default.
- W2626606311 cites W2055022588 @default.
- W2626606311 cites W2057990302 @default.
- W2626606311 cites W2058985417 @default.
- W2626606311 cites W2071249470 @default.
- W2626606311 cites W2078138301 @default.
- W2626606311 cites W2078281648 @default.
- W2626606311 cites W2078472264 @default.
- W2626606311 cites W2078669750 @default.
- W2626606311 cites W2079756964 @default.
- W2626606311 cites W2082442609 @default.
- W2626606311 cites W2083357340 @default.
- W2626606311 cites W2086079901 @default.
- W2626606311 cites W2086815629 @default.
- W2626606311 cites W2089238459 @default.
- W2626606311 cites W2095192286 @default.
- W2626606311 cites W2109145685 @default.
- W2626606311 cites W2109455664 @default.
- W2626606311 cites W2109941922 @default.
- W2626606311 cites W2111183040 @default.
- W2626606311 cites W2119686333 @default.
- W2626606311 cites W2123827414 @default.
- W2626606311 cites W2131286700 @default.
- W2626606311 cites W2137300354 @default.
- W2626606311 cites W2139498893 @default.
- W2626606311 cites W2140130453 @default.
- W2626606311 cites W2141157874 @default.
- W2626606311 cites W2145502099 @default.
- W2626606311 cites W2148144810 @default.
- W2626606311 cites W2155552623 @default.
- W2626606311 cites W2155639426 @default.
- W2626606311 cites W2157495054 @default.
- W2626606311 cites W2158855280 @default.
- W2626606311 cites W2161484327 @default.
- W2626606311 cites W2164754533 @default.
- W2626606311 cites W2170625826 @default.
- W2626606311 cites W2171222823 @default.
- W2626606311 cites W2171819173 @default.
- W2626606311 cites W2201115366 @default.
- W2626606311 cites W2288271511 @default.
- W2626606311 cites W2347176447 @default.
- W2626606311 cites W2461890012 @default.
- W2626606311 cites W2467196689 @default.
- W2626606311 cites W2468892893 @default.
- W2626606311 cites W2520347846 @default.
- W2626606311 cites W2617187727 @default.
- W2626606311 cites W2951377435 @default.
- W2626606311 cites W60878782 @default.
- W2626606311 doi "https://doi.org/10.1101/147959" @default.
- W2626606311 hasPublicationYear "2017" @default.
- W2626606311 type Work @default.