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• W2626798743 abstract "Classical cadherins are a metazoan-specific family of homophilic cell-cell adhesion molecules that regulate morphogenesis. Type I and type IV cadherins in this family function at adherens junctions in the major epithelial tissues of vertebrates and insects, respectively, but they have distinct, relatively simple domain organizations that are thought to have evolved by independent reductive changes from an ancestral type III cadherin, which is larger than derived paralogs and has a complicated domain organization. Although both type III and type IV cadherins have been identified in hexapods and branchiopods, the process by which the type IV cadherin evolved is still largely unclear.Through an analysis of arthropod genome sequences, we found that the only classical cadherin encoded in chelicerate genomes was the type III cadherin and that the two type III cadherin genes found in the spider Parasteatoda tepidariorum genome exhibited a complex yet ancestral exon-intron organization in arthropods. Genomic and transcriptomic data from branchiopod, copepod, isopod, amphipod, and decapod crustaceans led us to redefine the type IV cadherin category, which we separated into type IVa and type IVb, which displayed a similar domain organization, except type IVb cadherins have a larger number of extracellular cadherin (EC) domains than do type IVa cadherins (nine versus seven). We also showed that type IVa cadherin genes occurred in the hexapod, branchiopod, and copepod genomes whereas only type IVb cadherin genes were present in malacostracans. Furthermore, comparative characterization of the type IVb cadherins suggested that the presence of two extra EC domains in their N-terminal regions represented primitive characteristics. In addition, we identified an evolutionary loss of two highly conserved cysteine residues among the type IVa cadherins of insects.We provide a genomic perspective of the evolution of classical cadherins among bilaterians, with a focus on the Arthropoda, and suggest that following the divergence of early arthropods, the precursor of the insect type IV cadherin evolved through stepwise reductive changes from the ancestral type III state. In addition, the complementary distributions of polarized genomic characters related to type IVa/IVb cadherins may have implications for our interpretations of pancrustacean phylogeny." @default.
• W2626798743 created "2017-06-23" @default.
• W2626798743 creator A5015246910 @default.
• W2626798743 creator A5069513401 @default.
• W2626798743 creator A5080122012 @default.
• W2626798743 date "2017-06-17" @default.
• W2626798743 modified "2023-10-03" @default.
• W2626798743 title "Evolutionary origin of type IV classical cadherins in arthropods" @default.
• W2626798743 cites W1220385903 @default.
• W2626798743 cites W1486325159 @default.
• W2626798743 cites W1541986588 @default.
• W2626798743 cites W1563514911 @default.
• W2626798743 cites W1579830144 @default.
• W2626798743 cites W1611631396 @default.
• W2626798743 cites W1876693625 @default.
• W2626798743 cites W1939621514 @default.
• W2626798743 cites W1964690169 @default.
• W2626798743 cites W1966111055 @default.
• W2626798743 cites W1968272413 @default.
• W2626798743 cites W1973131553 @default.
• W2626798743 cites W1975548496 @default.
• W2626798743 cites W1976267533 @default.
• W2626798743 cites W1977259479 @default.
• W2626798743 cites W1978609854 @default.
• W2626798743 cites W1979390001 @default.
• W2626798743 cites W1981004291 @default.
• W2626798743 cites W1981859893 @default.
• W2626798743 cites W1985445286 @default.
• W2626798743 cites W1986802403 @default.
• W2626798743 cites W1992167522 @default.
• W2626798743 cites W1995736912 @default.
• W2626798743 cites W1996750562 @default.
• W2626798743 cites W1997829811 @default.
• W2626798743 cites W2000367724 @default.
• W2626798743 cites W2004095764 @default.
• W2626798743 cites W2009371644 @default.
• W2626798743 cites W2009666369 @default.
• W2626798743 cites W2011812152 @default.
• W2626798743 cites W2012180660 @default.
• W2626798743 cites W2012220164 @default.
• W2626798743 cites W2015114060 @default.
• W2626798743 cites W2017495685 @default.
• W2626798743 cites W2026452624 @default.
• W2626798743 cites W2031493923 @default.
• W2626798743 cites W2032313893 @default.
• W2626798743 cites W2032930150 @default.
• W2626798743 cites W2036496674 @default.
• W2626798743 cites W2041677910 @default.
• W2626798743 cites W2045344258 @default.
• W2626798743 cites W2056568233 @default.
• W2626798743 cites W2056922439 @default.
• W2626798743 cites W2057974199 @default.
• W2626798743 cites W2058214637 @default.
• W2626798743 cites W2058571198 @default.
• W2626798743 cites W2062955619 @default.
• W2626798743 cites W2064647489 @default.
• W2626798743 cites W2070265958 @default.
• W2626798743 cites W2076320557 @default.
• W2626798743 cites W2076877143 @default.
• W2626798743 cites W2079141278 @default.
• W2626798743 cites W2079193485 @default.
• W2626798743 cites W2081890316 @default.
• W2626798743 cites W2086776656 @default.
• W2626798743 cites W2089883236 @default.
• W2626798743 cites W2090379367 @default.
• W2626798743 cites W2096256651 @default.
• W2626798743 cites W2096549168 @default.
• W2626798743 cites W2099371924 @default.
• W2626798743 cites W2100930833 @default.
• W2626798743 cites W2107158607 @default.
• W2626798743 cites W2109636763 @default.
• W2626798743 cites W2114732932 @default.
• W2626798743 cites W2123046057 @default.
• W2626798743 cites W2123647329 @default.
• W2626798743 cites W2130672171 @default.
• W2626798743 cites W2131101891 @default.
• W2626798743 cites W2131459995 @default.
• W2626798743 cites W2141309821 @default.
• W2626798743 cites W2141506506 @default.
• W2626798743 cites W2146934540 @default.
• W2626798743 cites W2151103961 @default.
• W2626798743 cites W2169621308 @default.
• W2626798743 cites W2171004596 @default.
• W2626798743 cites W2185492685 @default.
• W2626798743 cites W2224875367 @default.
• W2626798743 cites W2293946955 @default.
• W2626798743 cites W2311203695 @default.
• W2626798743 cites W2495699100 @default.
• W2626798743 cites W2513699403 @default.
• W2626798743 cites W2950541841 @default.
• W2626798743 cites W4210969227 @default.
• W2626798743 cites W2415275613 @default.
• W2626798743 doi "https://doi.org/10.1186/s12862-017-0991-2" @default.
• W2626798743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5473995" @default.
• W2626798743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28623893" @default.
• W2626798743 hasPublicationYear "2017" @default.
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