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- W2626807114 endingPage "168" @default.
- W2626807114 startingPage "137" @default.
- W2626807114 abstract "Peptaibols and the related peptaibiotics are linear, amphipathic polypeptides. More than 300 of these secondary metabolites have been described to date. These compounds are composed of 5-20 amino acids and are generally produced in microheterogeneous mixtures. Peptaibols and peptaibiotics with unusual amino acid content are the result of non-ribosomal biosynthesis. Large multifunctional enzymes known as peptide synthetases assemble these molecules by the multiple carrier thiotemplate mechanism from a remarkable range of precursors, which can be N-methylated, acylated or reduced. Peptaibols and peptaibiotics show interesting physico-chemical and biological properties including the formation of pores in bilayer lipid membranes, as well as antibacterial, antifungal, occasionally antiviral activities, and may elicit plant resistance. The three-dimensional structure of peptaibols and peptaibiotics is characterized predominantly by one type of the helical motifs a-helix, 310-helix and b-bend ribbon spiral. The aim of this review is to summarize the data available about the biosynthesis, biological activity and conformational properties of peptaibols and peptaibiotics described from Trichoderma species." @default.
- W2626807114 created "2017-06-23" @default.
- W2626807114 creator A5002029295 @default.
- W2626807114 creator A5007930515 @default.
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- W2626807114 creator A5043110283 @default.
- W2626807114 creator A5055987253 @default.
- W2626807114 creator A5060882224 @default.
- W2626807114 date "2005-06-01" @default.
- W2626807114 modified "2023-10-18" @default.
- W2626807114 title "Peptaibols and Related Peptaibiotics of<i>Trichoderma</i>" @default.
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