FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2626854323> ?p ?o ?g. }

• W2626854323 endingPage "1334503" @default.
• W2626854323 startingPage "1334503" @default.
• W2626854323 abstract "Periodontitis is an inflammatory disease induced by pathogenic bacteria such as Porphyromonas gingivalis. Little is known about epidermal growth factor (EGF) signals in human gingival epithelial cells (HGEC), which are major targets of P. gingivalis, and how the expression of proteins participating in EGF signaling-that is, EGF-receptor (EGFR), suppressor of cytokine signaling-3 (SOCS-3), interferon regulatory factor-1 (IRF-1), and signal transducers and activators of transcription (STAT-3)-are modified. This study aimed to assess the effects of P. gingivalis and its purified lipopolysaccharide (LPS-Pg) on EGF signaling. HGEC were infected for 2 h in a dose-dependent manner with P. gingivalis and with heat-killed P. gingivalis, and activated for 2 and 24 h by 1 µg/mL of purified LPS-Pg. Quantitative reverse transcription polymerase chain reaction and Western blotting were performed to measure mRNA and protein levels for SOCS-3, IRF-1 EGF, EGFR, and STAT-3. The tyrosine-phosphorylation status of STAT-3 was also examined. The results showed that infection of HGEC cells with P. gingivalis, but not with heat-killed P. gingivalis, led to significant reductions in expression levels of mRNAs and proteins for SOCS-3, IRF-1, and EGFR, while LPS-Pg over time significantly increased the expression of these mRNAs and proteins. Tyrosine-phosphorylation of STAT-3 was significantly increased during infection with P. gingivalis and activation by LPS-Pg but not modified during infection with heat-killed P. gingivalis. This study highlights that P. gingivalis and its purified LPS differentially modulated the expression of proteins (SOCS-3, IRF-1, EGFR, and STAT-3) interfering with EGF signaling." @default.
• W2626854323 created "2017-06-23" @default.
• W2626854323 creator A5020489669 @default.
• W2626854323 creator A5044640849 @default.
• W2626854323 creator A5062720421 @default.
• W2626854323 creator A5081011015 @default.
• W2626854323 date "2017-01-01" @default.
• W2626854323 modified "2023-09-25" @default.
• W2626854323 title "<i>Porphyromonas gingivalis</i> and its lipopolysaccharide differently modulate epidermal growth factor–dependent signaling in human gingival epithelial cells" @default.
• W2626854323 cites W1510636715 @default.
• W2626854323 cites W1538233951 @default.
• W2626854323 cites W1565394933 @default.
• W2626854323 cites W1943338444 @default.
• W2626854323 cites W1966593361 @default.
• W2626854323 cites W1970794616 @default.
• W2626854323 cites W1971855867 @default.
• W2626854323 cites W1972515370 @default.
• W2626854323 cites W1986488805 @default.
• W2626854323 cites W2010538668 @default.
• W2626854323 cites W2013595009 @default.
• W2626854323 cites W2013894061 @default.
• W2626854323 cites W2017105065 @default.
• W2626854323 cites W2018969070 @default.
• W2626854323 cites W2021838232 @default.
• W2626854323 cites W2035473931 @default.
• W2626854323 cites W2050392927 @default.
• W2626854323 cites W2051896476 @default.
• W2626854323 cites W2056821401 @default.
• W2626854323 cites W2058777573 @default.
• W2626854323 cites W2060175990 @default.
• W2626854323 cites W2061067592 @default.
• W2626854323 cites W2080738413 @default.
• W2626854323 cites W2088034330 @default.
• W2626854323 cites W2090915646 @default.
• W2626854323 cites W2097097666 @default.
• W2626854323 cites W2106754325 @default.
• W2626854323 cites W2119384022 @default.
• W2626854323 cites W2119657383 @default.
• W2626854323 cites W2123581286 @default.
• W2626854323 cites W2124631347 @default.
• W2626854323 cites W2140013858 @default.
• W2626854323 cites W2145305106 @default.
• W2626854323 cites W2148142359 @default.
• W2626854323 cites W2158572100 @default.
• W2626854323 cites W2166313509 @default.
• W2626854323 cites W2183958987 @default.
• W2626854323 cites W2411225609 @default.
• W2626854323 cites W2444282594 @default.
• W2626854323 cites W2597296586 @default.
• W2626854323 cites W4232002237 @default.
• W2626854323 cites W76999708 @default.
• W2626854323 doi "https://doi.org/10.1080/20002297.2017.1334503" @default.
• W2626854323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5508388" @default.
• W2626854323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28748038" @default.
• W2626854323 hasPublicationYear "2017" @default.
• W2626854323 type Work @default.
• W2626854323 sameAs 2626854323 @default.
• W2626854323 citedByCount "10" @default.
• W2626854323 countsByYear W26268543232018 @default.
• W2626854323 countsByYear W26268543232019 @default.
• W2626854323 countsByYear W26268543232020 @default.
• W2626854323 countsByYear W26268543232021 @default.
• W2626854323 countsByYear W26268543232022 @default.
• W2626854323 crossrefType "journal-article" @default.
• W2626854323 hasAuthorship W2626854323A5020489669 @default.
• W2626854323 hasAuthorship W2626854323A5044640849 @default.
• W2626854323 hasAuthorship W2626854323A5062720421 @default.
• W2626854323 hasAuthorship W2626854323A5081011015 @default.
• W2626854323 hasBestOaLocation W26268543231 @default.
• W2626854323 hasConcept C11960822 @default.
• W2626854323 hasConcept C153911025 @default.
• W2626854323 hasConcept C170493617 @default.
• W2626854323 hasConcept C185592680 @default.
• W2626854323 hasConcept C203014093 @default.
• W2626854323 hasConcept C2776362946 @default.
• W2626854323 hasConcept C2777553839 @default.
• W2626854323 hasConcept C2778690821 @default.
• W2626854323 hasConcept C2778754761 @default.
• W2626854323 hasConcept C2780183776 @default.
• W2626854323 hasConcept C523546767 @default.
• W2626854323 hasConcept C54355233 @default.
• W2626854323 hasConcept C55493867 @default.
• W2626854323 hasConcept C62478195 @default.
• W2626854323 hasConcept C86803240 @default.
• W2626854323 hasConcept C89423630 @default.
• W2626854323 hasConcept C95444343 @default.
• W2626854323 hasConceptScore W2626854323C11960822 @default.
• W2626854323 hasConceptScore W2626854323C153911025 @default.
• W2626854323 hasConceptScore W2626854323C170493617 @default.
• W2626854323 hasConceptScore W2626854323C185592680 @default.
• W2626854323 hasConceptScore W2626854323C203014093 @default.
• W2626854323 hasConceptScore W2626854323C2776362946 @default.
• W2626854323 hasConceptScore W2626854323C2777553839 @default.
• W2626854323 hasConceptScore W2626854323C2778690821 @default.
• W2626854323 hasConceptScore W2626854323C2778754761 @default.
• W2626854323 hasConceptScore W2626854323C2780183776 @default.
• W2626854323 hasConceptScore W2626854323C523546767 @default.
• W2626854323 hasConceptScore W2626854323C54355233 @default.

• next