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- W2626877551 abstract "The activation of resident microglial cells, alongside the infiltration of peripheral macrophages, are key neuroinflammatory responses to traumatic brain injury (TBI) that are directly associated with neuronal death. Sexual disparities in response to TBI have been previously reported; however it is unclear whether a sex difference exists in neuroinflammatory progression after TBI. We exposed male and female mice to moderate-to-severe controlled cortical impact injury and studied glial cell activation in the acute and chronic stages of TBI using immunofluorescence and in situ hybridization analysis. We found that the sex response was completely divergent up to 7 days postinjury. TBI caused a rapid and pronounced cortical microglia/macrophage activation in male mice with a prominent activated phenotype that produced both pro- (IL-1β and TNFα) and anti-inflammatory (Arg1 and TGFβ) cytokines with a single-phase, sustained peak from 1 to 7 days. In contrast, TBI caused a less robust microglia/macrophage phenotype in females with biphasic pro-inflammatory response peaks at 4 h and 7 days, and a delayed anti-inflammatory mRNA peak at 30 days. We further report that female mice were protected against acute cell loss after TBI, with male mice demonstrating enhanced astrogliosis, neuronal death, and increased lesion volume through 7 days post-TBI. Collectively, these findings indicate that TBI leads to a more aggressive neuroinflammatory profile in male compared with female mice during the acute and subacute phases postinjury. Understanding how sex affects the course of neuroinflammation following brain injury is a vital step toward developing personalized and effective treatments for TBI." @default.
- W2626877551 created "2017-06-23" @default.
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- W2626877551 creator A5087752305 @default.
- W2626877551 creator A5087941071 @default.
- W2626877551 date "2017-06-13" @default.
- W2626877551 modified "2023-10-17" @default.
- W2626877551 title "Sexual dimorphism in the inflammatory response to traumatic brain injury" @default.
- W2626877551 cites W1497879842 @default.
- W2626877551 cites W1571044946 @default.
- W2626877551 cites W1757695926 @default.
- W2626877551 cites W1768846296 @default.
- W2626877551 cites W1830916283 @default.
- W2626877551 cites W1838129259 @default.
- W2626877551 cites W1874568289 @default.
- W2626877551 cites W1892097089 @default.
- W2626877551 cites W1967544208 @default.
- W2626877551 cites W1970991292 @default.
- W2626877551 cites W1972296893 @default.
- W2626877551 cites W1978186585 @default.
- W2626877551 cites W1980147601 @default.
- W2626877551 cites W1980372823 @default.
- W2626877551 cites W1981988940 @default.
- W2626877551 cites W1984737307 @default.
- W2626877551 cites W1998878159 @default.
- W2626877551 cites W2009058153 @default.
- W2626877551 cites W2011414645 @default.
- W2626877551 cites W2011538856 @default.
- W2626877551 cites W2013001148 @default.
- W2626877551 cites W2018562925 @default.
- W2626877551 cites W2025641775 @default.
- W2626877551 cites W2025828188 @default.
- W2626877551 cites W2029939494 @default.
- W2626877551 cites W2034775781 @default.
- W2626877551 cites W2035277900 @default.
- W2626877551 cites W2035408187 @default.
- W2626877551 cites W2036636601 @default.
- W2626877551 cites W2043020388 @default.
- W2626877551 cites W2049201207 @default.
- W2626877551 cites W2063743512 @default.
- W2626877551 cites W2067003329 @default.
- W2626877551 cites W2067267561 @default.
- W2626877551 cites W2067451082 @default.
- W2626877551 cites W2069893872 @default.
- W2626877551 cites W2074676727 @default.
- W2626877551 cites W2076186429 @default.
- W2626877551 cites W2076444759 @default.
- W2626877551 cites W2078253393 @default.
- W2626877551 cites W2079879731 @default.
- W2626877551 cites W2082429191 @default.
- W2626877551 cites W2086071094 @default.
- W2626877551 cites W2087318599 @default.
- W2626877551 cites W2090862497 @default.
- W2626877551 cites W2094660330 @default.
- W2626877551 cites W2095444837 @default.
- W2626877551 cites W2096225770 @default.
- W2626877551 cites W2099451408 @default.
- W2626877551 cites W2111433735 @default.
- W2626877551 cites W2112880160 @default.
- W2626877551 cites W2115825207 @default.
- W2626877551 cites W2116587655 @default.
- W2626877551 cites W2124836944 @default.
- W2626877551 cites W2131211125 @default.
- W2626877551 cites W2131686384 @default.
- W2626877551 cites W2136581644 @default.
- W2626877551 cites W2136742966 @default.
- W2626877551 cites W2137368645 @default.
- W2626877551 cites W2140178129 @default.
- W2626877551 cites W2140380746 @default.
- W2626877551 cites W2145695478 @default.
- W2626877551 cites W2146795905 @default.
- W2626877551 cites W2148807460 @default.
- W2626877551 cites W2156900094 @default.
- W2626877551 cites W2163231981 @default.
- W2626877551 cites W2172188218 @default.
- W2626877551 cites W2209119157 @default.
- W2626877551 cites W2255941445 @default.
- W2626877551 cites W2278150775 @default.
- W2626877551 cites W2345917271 @default.
- W2626877551 cites W2407337075 @default.
- W2626877551 cites W2499640845 @default.
- W2626877551 cites W2527900667 @default.
- W2626877551 cites W2553161190 @default.
- W2626877551 cites W2555637551 @default.
- W2626877551 cites W2589516850 @default.
- W2626877551 cites W2594403755 @default.
- W2626877551 doi "https://doi.org/10.1002/glia.23171" @default.
- W2626877551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5609840" @default.
- W2626877551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28608978" @default.
- W2626877551 hasPublicationYear "2017" @default.
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