FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2627008901> ?p ?o ?g. }

• W2627008901 abstract "Erectile dysfunction (ED) significantly reduces quality of life and is an early warning of cardiovascular disease. The prevalence of ED is higher among hypertensive compared to normotensive men. Activation of the immune system has been implicated in the development of hypertension; however, the role of the immune system in the development of ED remains unknown. In this study, we hypothesized that TLR2, a key player in innate immunity, is increased leading to an inflammatory response in the corpus cavernosum of hypertensive rats. We induced hypertension in male Sprague Dawley (SD) rats (age 15-weeks) via administration of N (G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, for 4 weeks in drinking water (500mg/L). Our results showed that the mean systolic blood pressure from L-NAME treated rats was significantly greater (p<0.05) compared to controls (208±33 vs 121±3mmHg). Western blot analysis demonstrated that protein expressions of TLR2, along with its primary intra-cellular signaling protein, myeloid differentiation primary response protein 88 (MyD88), were higher in the corpus cavernosum from L-NAME-treated rats compared to controls (1.691±0.2 vs 1.000±0.1) and (2.177±0.2 vs 1.000±0.3), respectively. Our results also showed that, there is an increase in the phosphorylation of the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα) in the corpus cavernosum from L-NAME-treated rats compared to controls (2.038±0.2 vs 1.000±0.2). Additionally, the cavernosal tissue expression levels of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) was also increased in the L-NAME-treated group compared to control (2.757±0.4 vs 1.000±0.3). Together, these data suggest that increased activation of TLR2 may initiate an inflammatory response which may lead to corpus cavernosum dysfunction, potentially contributing to ED in a rat model of hypertension induced via nitric oxide synthase inhibition." @default.
• W2627008901 created "2017-06-23" @default.
• W2627008901 creator A5006073578 @default.
• W2627008901 creator A5025126662 @default.
• W2627008901 creator A5028789700 @default.
• W2627008901 creator A5030845503 @default.
• W2627008901 date "2012-09-01" @default.
• W2627008901 modified "2023-10-12" @default.
• W2627008901 title "Abstract 183: Hypertension Increases Toll-Like Receptor 2 (TLR2) and Inflammatory Cytokine Expression in the Corpus Cavernosum From Sprague Dawley Rats" @default.
• W2627008901 doi "https://doi.org/10.1161/hyp.60.suppl_1.a183" @default.
• W2627008901 hasPublicationYear "2012" @default.
• W2627008901 type Work @default.
• W2627008901 sameAs 2627008901 @default.
• W2627008901 citedByCount "0" @default.
• W2627008901 crossrefType "journal-article" @default.
• W2627008901 hasAuthorship W2627008901A5006073578 @default.
• W2627008901 hasAuthorship W2627008901A5025126662 @default.
• W2627008901 hasAuthorship W2627008901A5028789700 @default.
• W2627008901 hasAuthorship W2627008901A5030845503 @default.
• W2627008901 hasConcept C126322002 @default.
• W2627008901 hasConcept C134018914 @default.
• W2627008901 hasConcept C136449434 @default.
• W2627008901 hasConcept C170493617 @default.
• W2627008901 hasConcept C203014093 @default.
• W2627008901 hasConcept C2777622882 @default.
• W2627008901 hasConcept C2778690821 @default.
• W2627008901 hasConcept C2779929075 @default.
• W2627008901 hasConcept C2781236682 @default.
• W2627008901 hasConcept C519581460 @default.
• W2627008901 hasConcept C71924100 @default.
• W2627008901 hasConcept C84393581 @default.
• W2627008901 hasConcept C8891405 @default.
• W2627008901 hasConceptScore W2627008901C126322002 @default.
• W2627008901 hasConceptScore W2627008901C134018914 @default.
• W2627008901 hasConceptScore W2627008901C136449434 @default.
• W2627008901 hasConceptScore W2627008901C170493617 @default.
• W2627008901 hasConceptScore W2627008901C203014093 @default.
• W2627008901 hasConceptScore W2627008901C2777622882 @default.
• W2627008901 hasConceptScore W2627008901C2778690821 @default.
• W2627008901 hasConceptScore W2627008901C2779929075 @default.
• W2627008901 hasConceptScore W2627008901C2781236682 @default.
• W2627008901 hasConceptScore W2627008901C519581460 @default.
• W2627008901 hasConceptScore W2627008901C71924100 @default.
• W2627008901 hasConceptScore W2627008901C84393581 @default.
• W2627008901 hasConceptScore W2627008901C8891405 @default.
• W2627008901 hasIssue "suppl_1" @default.
• W2627008901 hasLocation W26270089011 @default.
• W2627008901 hasOpenAccess W2627008901 @default.
• W2627008901 hasPrimaryLocation W26270089011 @default.
• W2627008901 hasRelatedWork W1966234050 @default.
• W2627008901 hasRelatedWork W2008087125 @default.
• W2627008901 hasRelatedWork W2033472167 @default.
• W2627008901 hasRelatedWork W2034583712 @default.
• W2627008901 hasRelatedWork W2063619316 @default.
• W2627008901 hasRelatedWork W2074821979 @default.
• W2627008901 hasRelatedWork W2089295326 @default.
• W2627008901 hasRelatedWork W2169225653 @default.
• W2627008901 hasRelatedWork W2171089442 @default.
• W2627008901 hasRelatedWork W2414846389 @default.
• W2627008901 hasVolume "60" @default.
• W2627008901 isParatext "false" @default.
• W2627008901 isRetracted "false" @default.
• W2627008901 magId "2627008901" @default.
• W2627008901 workType "article" @default.