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- W2627128521 abstract "目的：探讨缺硒致鸡心肌损伤的代谢组学变化。方法：选用1日龄雏鸡，采用低硒饲料喂养建立鸡缺硒心肌损伤模型；通过血浆代谢组学方法检测差异代谢物质。结果：发现正负离子状态下，缺硒组血浆均有显著差异代谢物质，共计16种。其中显著上调表达的有胆碱、磷脂酰甘油、和亮氨酸(P < 0.01)。结论：在缺硒组中观察到甘油、磷脂、亮氨酸、类固醇等生化物质的异常代谢。这些潜在的生物标志物与炎症、凋亡、和血小板聚集有关。可初步为深入理解鸡缺硒心肌损伤代谢机制提供新的信息。 Research purposes: Study on the changes of myocardial injury induced by selenium deficiency in chicken. Methods: 1-day old chicks with low selenium feed were chosen to build the chicken selenium deficient myocardial injury model. Plasma metabonomics analysis was applied to detect the differential metabolites. Results: There were 16 differential metabolites in selenium deficient plasma in positive and negative ion state. Among them, the abundance of choline, phosphatidyl glycerol and leucine were up-regulated (P < 0.01). Conclusion: Abnormal metabolism of glycerol and phospholipids, leucine, steroids and other biochemical substances were found in selenium deficiency group. These potential biomarkers are associated with inflammation, apoptosis, and platelet aggregation. It can provide new information for understanding the metabolic mechanism of selenium deficiency in chicken." @default.
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- W2627128521 date "2017-01-01" @default.
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- W2627128521 title "Metabonomics Analysis of Myocardial Injury Induced by Selenium Deficiency in Chicken" @default.
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- W2627128521 doi "https://doi.org/10.12677/ojns.2017.52018" @default.
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