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- W262990827 abstract "[Objective ] To investigate the expression of RASSF1A protein in the tissue microarrays of hepatocellular carcinoma (HCC) and its clinical significance. [Methods] The tissue microarrays comprised 98 cases of HCC tissues, 89 non-cancerous liver tissues and 24 cases of para-cancerous liver tissues. Immunohistochemistry was employed to detect the expression of RASSF1A proteins. Statistic analysis was made to figure out the correlation between the expression and the clinicopathological features of HCC. [Results] (1) There were 205 cases that could be used in the tissue microarrays (utilization rate was 97.16%, 205 / 211); (2) The expression of RASSF1A protein definitely located in cytoplasma of HCC; (3) The positive rate of RASSF1A in HCC tissues was 39.58% (38 / 96), significantly lower than that in the non-cancerous liver tissues 57.65% (49 / 85, P = 0.015) and the para-HCC tissues 66.67% (16 / 24, P = 0.017); (4) The positive rate of RASSF1A in HCC tissues in the clinical TNM stageⅠ, Ⅱ was 57.38% (35 / 61), significantly higher than that in the stage Ⅲ, Ⅳ8.57% (3 / 35, P = 0.000); (5) The positive rate of RASSF1A in the cases without metastasis within 20 months was 63.64% (28 / 44), significantly higher than that in the group with metastasis4.88% (2 / 41, P = 0.000); (6) The RASSF1A expression in the groups of﹤50 years (16 / 54, 29.63%), AFP≥400μg / L (14 / 55, 25.45%), portal vein tumor embolus (3 / 31, 6.98%), capsular infiltration (16 / 64, 25%) and multiple tumor nodes (5 / 31, 16.13%) were significantly lower than that in the groups of ≥50 years (22 / 42, 52.38%, P = 0.024), AFP﹤400μg / L (24 / 41, 58.54%, P = 0.002), without tumor embolus (35 / 65, 53.85%, P = 0.000), with no capsular infiltration (22 / 32, 68.75%, P = 0.000) and single node (33 / 65, 50.77%, P = 0.000), while it was not associated with patients’ sex, histological classification, cirrhosis or tumor size. [Conclusion] Tissue microarrays technique is a feasible, rapid, economic and accurate approach for screening clinical tissue specimens on a large scale. The loss or abnormal down-regulation of RASSF1A protein expression may play an important role in the pathogenesis, development and metastases of HCC. RASSF1A gene may serve as an important molecular biological indicator in diagnosing and predicating the biological behavior of HCC patients." @default.
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- W262990827 date "2009-01-01" @default.
- W262990827 modified "2023-09-24" @default.
- W262990827 title "Expression of RASSF1A proteins in tissue microarrays of primary hepatocellular carcinoma and its clinical significance." @default.
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