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- W263065278 abstract "ABSTRACT BACKGROUND RESULTS RESULTS 116 HIV -1 infected children who initiated HAART aged below 5years were recruited into a cohort at JCRC in Kampala, Uganda. 41 of these children (63.4% girls, median age 6months at HAART initiation ) had perinatal exposure to Single dose Nevirapine For 20 of these children (15 exposed and 5 unexposed) that had virologic failure (Viral load <400 copies/ml) at week 24 and/ or week 48 following initiation of NNRTI based HAART, we studied the NNRTI and the NRTI associated mutations by genotypic resistance testing Genotypic resistance sequencing was done using in house primers The sequences were edited using BioEdit Sequence Alignment Editor (Version 7.0.5) and analysed using the HIV drug resistance database of Stanford University. HIV infected children perinatally exposed to SDN with virologic failure on NNRTI based HAART have multiple NNRTI and NRTI drug resistance mutationsFewer mutations were observed in the children with no prior SDN exposure, making the SDN exposed children with virologic failure more likely to have multiple drug resistance" @default.
- W263065278 created "2016-06-24" @default.
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- W263065278 date "2010-01-01" @default.
- W263065278 modified "2023-09-27" @default.
- W263065278 title "Antiretroviral Drug Resistance Mutations in HIV-1 Infected Ugandan Children Perinatally Exposed to Single Dose Nevirapine Following Virologic Failure to an NNRTI Based Regimen" @default.
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